4.6 Review

Epigenetic and Transcriptional Control of the Opioid Prodynorphine Gene: In-Depth Analysis in the Human Brain

Related references

Note: Only part of the references are listed.
Article Neurosciences

Efferent projections ofVglut2,Foxp2, andPdynparabrachial neurons in mice

Dake Huang et al.

Summary: This study compared the projection patterns of glutamatergic neurons, a subpopulation expressing the transcription factor Foxp2, and another subpopulation expressing the neuropeptide Pdyn in the PB region. Results indicate that genetic identity determines connectivity (and therefore, function), providing a framework for mapping all PB output projections based on the genetic identity of its neurons.

JOURNAL OF COMPARATIVE NEUROLOGY (2021)

Review Clinical Neurology

Spinocerebellar ataxia type 23 (SCA23): a review

Fan Wu et al.

Summary: Spinocerebellar ataxias (SCAs), formerly known as autosomal dominant cerebellar ataxias (ADCAs), are a group of hereditary heterogeneous neurodegenerative diseases characterized by symptoms such as gait, progressive ataxia, dysarthria, and eye movement disorder. Among the various subtypes, SCA23 is associated with a mutant prodynorphin gene and presents different clinical features.

JOURNAL OF NEUROLOGY (2021)

Article Neurosciences

Multiscale neurobiological correlates of human neuroticism

Qiang Xu et al.

HUMAN BRAIN MAPPING (2020)

Article Medicine, Research & Experimental

Novel Kappa Opioid Receptor Agonist as Improved PET Radiotracer: Development and in Vivo Evaluation

Songye Li et al.

MOLECULAR PHARMACEUTICS (2019)

Review Neurosciences

Functional consequences of neuropeptide and small-molecule co-transmission

Michael P. Nusbaum et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Letter Clinical Neurology

Damaged reward areas in human alcoholics: neuronal proportion decline and astrocyte activation

Daniil Sarkisyan et al.

ACTA NEUROPATHOLOGICA (2017)

Article Biochemistry & Molecular Biology

Opioid precursor protein isoform is targeted to the cell nuclei in the human brain

Olga Kononenko et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

Review Neurosciences

The landscape of DNA methylation amid a perfect storm of autism aetiologies

Annie Vogel Ciernia et al.

NATURE REVIEWS NEUROSCIENCE (2016)

Article Neurosciences

Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics

Daniil Sarkisyan et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Biotechnology & Applied Microbiology

Gateways to the FANTOM5 promoter level mammalian expression atlas

Marina Lizio et al.

GENOME BIOLOGY (2015)

Review Clinical Neurology

Human alcohol-related neuropathology

Suzanne M. de la Monte et al.

ACTA NEUROPATHOLOGICA (2014)

Article Biochemistry & Molecular Biology

PDYN, a gene implicated in brain/mental disorders, is targeted by REST in the adult human brain

Richard Henriksson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS (2014)

Article Neurosciences

The One-Two Punch of Alcoholism: Role of Central Amygdala Dynorphins/Kappa-Opioid Receptors

Jessica L. Kissler et al.

BIOLOGICAL PSYCHIATRY (2014)

Article Multidisciplinary Sciences

Dual role for Islet-1 in promoting striatonigral and repressing striatopallidal genetic programs to specify striatonigral cell identity

Kuan-Ming Lu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Editorial Material Multidisciplinary Sciences

Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation

Xuan Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area

John W. Muschamp et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Biochemical Research Methods

Comparison of REST Cistromes across Human Cell Types Reveals Common and Context-Specific Functions

Shira Rockowitz et al.

PLOS COMPUTATIONAL BIOLOGY (2014)

Article Clinical Neurology

Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states

Victor M. Karpyak et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2013)

Article Multidisciplinary Sciences

PDYN rs2281285 Variant Association with Drinking to Avoid Emotional or Somatic Discomfort

Ulrich W. Preuss et al.

PLOS ONE (2013)

Review Pharmacology & Pharmacy

Dynorphin-Still an Extraordinarily Potent Opioid Peptide

Charles Chavkin

MOLECULAR PHARMACOLOGY (2013)

Article Biochemistry & Molecular Biology

Repeated moderate-dose ethanol bouts impair cognitive function in Wistar rats

Alexander Kuzmin et al.

ADDICTION BIOLOGY (2012)

Review Biochemistry & Molecular Biology

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

H. A. Tejeda et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2012)

Article Biochemistry & Molecular Biology

Genetic-epigenetic interaction modulates μ-opioid receptor regulation

Bruno G. Oertel et al.

HUMAN MOLECULAR GENETICS (2012)

Review Biochemistry & Molecular Biology

Ca2+-dependent Transcriptional Control of Ca2+ Homeostasis

Jose R. Naranjo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Multidisciplinary Sciences

Architecture of the human regulatory network derived from ENCODE data

Mark B. Gerstein et al.

NATURE (2012)

Review Endocrinology & Metabolism

The Opioid System and Food Intake: Homeostatic and Hedonic Mechanisms

Ruben Nogueiras et al.

OBESITY FACTS (2012)

Article Biochemistry & Molecular Biology

Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity

Morgane Rouault et al.

ADDICTION BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics

Malik Mumtaz Taqi et al.

ADDICTION BIOLOGY (2011)

Article Biochemistry & Molecular Biology

Imprinting in the schizophrenia candidate gene GABRB2 encoding GABAA receptor β2 subunit

F. W. Pun et al.

MOLECULAR PSYCHIATRY (2011)

Article Biochemistry & Molecular Biology

A genetic determinant of the striatal dopamine response to alcohol in men

V. A. Ramchandani et al.

MOLECULAR PSYCHIATRY (2011)

Review Clinical Neurology

Clinical and pathological features of alcohol-related brain damage

Natalie M. Zahr et al.

NATURE REVIEWS NEUROLOGY (2011)

Review Neurosciences

Transcriptional and epigenetic mechanisms of addiction

Alfred J. Robison et al.

NATURE REVIEWS NEUROSCIENCE (2011)

Article Biotechnology & Applied Microbiology

Tissue-specific DNA methylation of the human prodynorphin gene in post-mortem brain tissues and PBMCs

Vadim Yuferov et al.

PHARMACOGENETICS AND GENOMICS (2011)

Article Genetics & Heredity

Prodynorphin Mutations Cause the Neurodegenerative Disorder Spinocerebellar Ataxia Type 23

Georgy Bakalkin et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2010)

Article Neurosciences

Dynorphin, stress, and depression

Allison T. Knoll et al.

BRAIN RESEARCH (2010)

Review Neurosciences

Kinase cascades and ligand-directed signaling at the kappa opioid receptor

Michael R. Bruchas et al.

PSYCHOPHARMACOLOGY (2010)

Article Genetics & Heredity

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Asaf Hellman et al.

EPIGENETICS & CHROMATIN (2010)

Article Biotechnology & Applied Microbiology

SNP-based prediction of the human germ cell methylation landscape

Hehuang Xie et al.

GENOMICS (2009)

Article Clinical Neurology

Gene polymorphisms in prodynorphin (PDYN) are associated with episodic memory in the elderly

Heike Koelsch et al.

JOURNAL OF NEURAL TRANSMISSION (2009)

Article Neurosciences

Endogenous κ Opioid Activation Mediates Stress-Induced Deficits in Learning and Memory

Amanda N. Carey et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Multidisciplinary Sciences

MicroRNA-mediated switching of chromatin-remodelling complexes in neural development

Andrew S. Yoo et al.

NATURE (2009)

Article Biotechnology & Applied Microbiology

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells

Madeleine P. Ball et al.

NATURE BIOTECHNOLOGY (2009)

Review Pharmacology & Pharmacy

30 years of dynorphins - New insights on their functions in neuropsychiatric diseases

Christoph Schwarzer

PHARMACOLOGY & THERAPEUTICS (2009)

Article Biochemistry & Molecular Biology

A regulatory variation in OPRK1, the gene encoding the κ-opioid receptor, is associated with alcohol dependence

Howard J. Edenberg et al.

HUMAN MOLECULAR GENETICS (2008)

Article Neurosciences

The dysphoric component of stress is encoded by activation of the dynorphin κ-opioid system

Benjamin B. Land et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Multidisciplinary Sciences

CTCF-dependent enhancer-blocking by alternative chromatin loop formation

Chunhui Hou et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

Opioid neuropeptide genotypes in relation to heroin abuse: Dopamine tone contributes to reversed mesolimbic proenkephalin expression

Andrej Nikoshkov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Neurosciences

Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence

Brendan M. Walker et al.

NEUROPSYCHOPHARMACOLOGY (2008)

Article Geriatrics & Gerontology

Dysregulation of dynorphins in Alzheimer disease

T. Yakovleva et al.

NEUROBIOLOGY OF AGING (2007)

Review Pharmacology & Pharmacy

Dynorphin and the pathophysiology of drug addiction

T. S. Shippenberg et al.

PHARMACOLOGY & THERAPEUTICS (2007)

Article Genetics & Heredity

The opioid system in alcohol and drug dependence: Family-based association study

Xiaoling Xuei et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2007)

Article Biochemistry & Molecular Biology

Proenkephalin assists stress-activated apoptosis through transcriptional repression of NF-κB- and p53-regulated gene targets

N. McTavish et al.

CELL DEATH AND DIFFERENTIATION (2007)

Article Biochemistry & Molecular Biology

Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence

Tanya J. Williams et al.

ADDICTION BIOLOGY (2007)

Article Multidisciplinary Sciences

Genome-wide mapping of in vivo protein-DNA interactions

David S. Johnson et al.

SCIENCE (2007)

Article Biochemistry & Molecular Biology

Association of the κ-opioid system with alcohol dependence

X. Xuei et al.

MOLECULAR PSYCHIATRY (2006)

Article Genetics & Heredity

Genome-wide analysis of mammalian promoter architecture and evolution

Piero Carninci et al.

NATURE GENETICS (2006)

Article Neurosciences

Genetic variant of prodynorphin gene is risk factor for methamphetamine dependence

Akira Nomura et al.

NEUROSCIENCE LETTERS (2006)

Article Neurosciences

An essential role for ΔFosB in the nucleus accumbens in morphine action

V Zachariou et al.

NATURE NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

Ancient and recent positive selection transformed opioid cis-regulation in humans

MV Rockman et al.

PLOS BIOLOGY (2005)

Article Genetics & Heredity

A functional prodynorphin promoter polymorphism and opioid dependence

R Ray et al.

PSYCHIATRIC GENETICS (2005)

Article Genetics & Heredity

Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence

JP Dahl et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)

Article Biochemistry & Molecular Biology

Prodynorphin transcripts and proteins differentially expressed and regulated in the adult human brain

A Nikoshkov et al.

FASEB JOURNAL (2005)

Review Neurosciences

Stress and the brain:: From adaptation to disease

ER de Kloet et al.

NATURE REVIEWS NEUROSCIENCE (2005)

Article Neurosciences

Effects of κ-opioid receptor ligands on intracranial self-stimulation in rats

MS Todtenkopf et al.

PSYCHOPHARMACOLOGY (2004)

Article Neurosciences

△FosB:: a molecular switch for long-term adaptation in the brain

CA McClung et al.

MOLECULAR BRAIN RESEARCH (2004)

Article Genetics & Heredity

Complete sequencing and characterization of 21,243 full-length human cDNAs

T Ota et al.

NATURE GENETICS (2004)

Article Pharmacology & Pharmacy

Antidepressant-like effects of κ-opioid receptor antagonists in the forced swim test in rats

SD Mague et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)

Article Behavioral Sciences

Naloxone nonselective suppression of drinking of ethanol, sucrose, saccharin, and water by rats

MJ Cichelli et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2002)

Article Biochemistry & Molecular Biology

DREAM is a critical transcriptional repressor for pain modulation

HYM Cheng et al.

Article Pharmacology & Pharmacy

Opioids in chronic pain

R Przewlocki et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2001)

Article Oncology

Susceptibility of nonpromoter CpG islands to de novo methylation in normal and neoplastic cells

C Nguyen et al.

JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)

Article Biochemistry & Molecular Biology

DREAM-αCREM interaction via leucine-charged domains derepresses downstream regulatory element-dependent transcription

F Ledo et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Biochemistry & Molecular Biology

An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression

A Zimprich et al.

JOURNAL OF NEUROCHEMISTRY (2000)