Journal
MOLECULES
Volume 26, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/molecules26123692
Keywords
tea polyphenols; neuroprotective effect; intestinal flora; microbe-gut-brain axis
Funding
- Key Research and development program of Zhejiang Province [2018C02023]
- Research Foundation for the Taizhou Science and Technology Project [1801ny05]
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Tea polyphenols may exert neuroprotective effects by regulating intestinal microbiota and their metabolites, with the microbiota-gut-brain axis playing a critical role in this process.
Tea polyphenols (TPs) are the general compounds of natural polyhydroxyphenols extracted in tea. Although a large number of studies have shown that TPs have obvious neuroprotective and neuro repair effects, they are limited due to the low bioavailability in vivo. However, TPs can act indirectly on the central nervous system by affecting the microflora-gut-brain axis, in which the microbiota and its composition represent a factor that determines brain health. Bidirectional communication between the intestinal microflora and the brain (microbe-gut-brain axis) occurs through a variety of pathways, including the vagus nerve, immune system, neuroendocrine pathways, and bacteria-derived metabolites. This axis has been shown to influence neurotransmission and behavior, which is usually associated with neuropsychiatric disorders. In this review, we discuss that TPs and their metabolites may provide benefits by restoring the imbalance of intestinal microbiota and that TPs are metabolized by intestinal flora, to provide a new idea for TPs to play a neuroprotective role by regulating intestinal flora.
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