Journal
MOLECULES
Volume 26, Issue 18, Pages -Publisher
MDPI
DOI: 10.3390/molecules26185611
Keywords
Zopfiella sp; cytochalasins; Pseudomonas syringae pv; actinidiae; antibacterial
Funding
- National Natural Science Foundation of China [22177139, 22177138]
- National Key Research and Development Program of China [2017YFC1704007]
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In the search for antibacterial agents against Pseudomonas syringae pv. actinidiae (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A-D, were identified from the fungus Zopfiella sp. Compounds 1 and 3 showed antibacterial activity against Psa, marking the first report of cytochalasin derivatives with anti-Psa activity.
In our continuous search for antibacterial agents against Pseudomonas syringae pv. actinidiae (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A-D (1-4), were characterized from the fungus Zopfiella sp. The structures were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds 1 and 3 exhibited antibacterial activity against Psa with MIC values of 25 and 50 mu g/mL, respectively. This is the first report of anti-Psa activity of cytochalasin derivatives.
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