Journal
MOLECULES
Volume 26, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/molecules26175174
Keywords
chemokine receptor; chemokine; positron emission tomography (PET); in vivo imaging
Funding
- American Heart Association (AHA) Innovative Project Award (IPA) [18IPA34170351]
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Chemokines and their receptors play crucial roles in maintaining the physiological functions of various cells, especially immune cells. They guide leukocytes to respond to inflammatory reactions and infectious agents, as well as support the differentiation, proliferation, and metastasis of tumor cells. Advances in the development of radiotracers for chemokine receptors have shed new light on cancer and cardiovascular research and drug development.
Chemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells. The signals of chemokines/chemokine receptors guide various leukocytes to respond to inflammatory reactions and infectious agents. Many chemokine receptors play supportive roles in the differentiation, proliferation, angiogenesis, and metastasis of diverse tumor cells. In addition, the signaling functions of a few chemokine receptors are associated with cardiac, pulmonary, and brain disorders. Over the years, numerous promising molecules ranging from small molecules to short peptides and antibodies have been developed to study the role of chemokine receptors in healthy states and diseased states. These drug-like candidates are in turn exploited as radiolabeled probes for the imaging of chemokine receptors using noninvasive in vivo imaging, such as positron emission tomography (PET). Recent advances in the development of radiotracers for various chemokine receptors, particularly of CXCR4, CCR2, and CCR5, shed new light on chemokine-related cancer and cardiovascular research and the subsequent drug development. Here, we present the recent progress in PET radiotracer development for imaging of various chemokine receptors.
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