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Hongyan Wang et al.
CANCER RESEARCH (2013)
Lipoxygenase: An Emerging Target for Stroke Therapy
Klaus van Leyen
CNS & Neurological Disorders-Drug Targets (2013)
Tetramethylpyrazine reduces cellular inflammatory response following permanent focal cerebral ischemia in rats
Tsung-Kuei Kao et al.
EXPERIMENTAL NEUROLOGY (2013)
The potential to intensify sulforaphane formation in cooked broccoli (Brassica oleracea var. italica) using mustard seeds (Sinapis alba)
Sameer Khalil Ghawi et al.
FOOD CHEMISTRY (2013)
Sulforaphane preconditioning of the Nrf2/HO-1 defense pathway protects the cerebral vasculature against blood-brain barrier disruption and neurological deficits in stroke
Alessio Alfieri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance
Suryakant K. Niture et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Neohesperidin attenuates cerebral ischemia-reperfusion injury via inhibiting the apoptotic pathway and activating the Akt/Nrf2/HO-1 pathway
Ji-Jun Wang et al.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2013)
Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation
Yang Bai et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2013)
Docosahexaenoic acid reduces cellular inflammatory response following permanent focal cerebral ischemia in rats
Cheng-Yi Chang et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2013)
Temporal and spatial distribution of Nrf2 in rat brain following stroke: quantification of nuclear to cytoplasmic Nrf2 content using a novel immunohistochemical technique
Salil Srivastava et al.
JOURNAL OF PHYSIOLOGY-LONDON (2013)
Curcuminoids Limit Neutrophil-Mediated Reperfusion Injury in Experimental Stroke by Targeting the Endothelium
Janet L. Funk et al.
MICROCIRCULATION (2013)
被撤回的出版物: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet (Retracted article. See vol. 378, pg. 2441, 2018)
Ramon Estruch et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Curcumin Protects Human Keratinocytes against Inorganic Arsenite-Induced Acute Cytotoxicity through an NRF2-Dependent Mechanism
Rui Zhao et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Sulforaphane as a Potential Protective Phytochemical against Neurodegenerative Diseases
Andrea Tarozzi et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Curcumin Pretreatment Induces Nrf2 and an Antioxidant Response and Prevents Hemin-Induced Toxicity in Primary Cultures of Cerebellar Granule Neurons of Rats
Susana Gonzalez-Reyes et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2013)
Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway
Jingxian Wu et al.
PLOS ONE (2013)
A comparative study of PNIPAM nanoparticles of curcumin, demethoxycurcumin, and bisdemethoxycurcumin and their effects on oxidative stress markers in experimental stroke
Niyaz Ahmad et al.
PROTOPLASMA (2013)
Physical Activity Frequency and Risk of Incident Stroke in a National US Study of Blacks and Whites
Michelle N. McDonnell et al.
STROKE (2013)
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer
Emilia Kansanen et al.
REDOX BIOLOGY (2013)
The protection by Octreotide against experimental ischemic stroke: Up-regulated transcription factor Nrf2, HO-1 and down-regulated NF-κB expression
Linyu Chen et al.
BRAIN RESEARCH (2012)
Resveratrol prevents CA1 neurons against ischemic injury by parallel modulation of both GSK-3β and CREB through PI3-K/Akt pathways
Fabricio Simao et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2012)
Pathophysiologic cascades in ischemic stroke
Changhong Xing et al.
INTERNATIONAL JOURNAL OF STROKE (2012)
Dimethyl fumarate - only an anti-psoriatic medication?
Markus Meissner et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2012)
Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis
Suryakant K. Niture et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis
Patricia Rada et al.
MOLECULAR AND CELLULAR BIOLOGY (2012)
THE NUCLEAR FACTOR ERYTHROID 2-LIKE 2 ACTIVATOR, TERT-BUTYLHYDROQUINONE, IMPROVES COGNITIVE PERFORMANCE IN MICE AFTER MILD TRAUMATIC BRAIN INJURY
J. N. Saykally et al.
NEUROSCIENCE (2012)
Placebo-Controlled Phase 3 Study of Oral BG-12 or Glatiramer in Multiple Sclerosis
Robert J. Fox et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Placebo-Controlled Phase 3 Study of Oral BG-12 for Relapsing Multiple Sclerosis
Ralf Gold et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Trends in stroke hospitalizations and associated risk factors among children and young adults, 1995-2008
Mary G. George et al.
ANNALS OF NEUROLOGY (2011)
Pharmacological Targeting of the Transcription Factor Nrf2 at the Basal Ganglia Provides Disease Modifying Therapy for Experimental Parkinsonism
Agnieszka Jazwa et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
The anti-inflammatory effects of dimethyl fumarate in astrocytes involve glutathione and haem oxygenase-1
Shao Xia Lin et al.
ASN NEURO (2011)
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker et al.
BRAIN (2011)
Expression of Keap1-Nrf2 system and antioxidative proteins in mouse brain after transient middle cerebral artery occlusion
Nobuhito Tanaka et al.
BRAIN RESEARCH (2011)
Bioavailability of Sulforaphane from Two Broccoli Sprout Beverages: Results of a Short-term, Cross-over Clinical Trial in Qidong, China
Patricia A. Egner et al.
CANCER PREVENTION RESEARCH (2011)
Remote Ischemic Preconditioning Making the Brain More Tolerant, Safely and Inexpensively
Michael A. Moskowitz et al.
CIRCULATION (2011)
Ischemic insult induced apoptotic changes in PC12 cells: Protection by trans resveratrol
Megha Agrawal et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2011)
Fumarates improve psoriasis and multiple sclerosis by inducing type II dendritic cells
Kamran Ghoreschi et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
Delayed treatment with a novel neurotrophic compound reduces behavioral deficits in rabbit ischemic stroke
Paul A. Lapchak et al.
JOURNAL OF NEUROCHEMISTRY (2011)
p-hydroxybenzyl alcohol prevents brain injury and behavioral impairment by activating Nrf2, PDI, and neurotrophic factor genes in a rat model of brain ischemia
Kyung-Yoon Kam et al.
MOLECULES AND CELLS (2011)
Resveratrol Pretreatment Attenuates Cerebral Ischemic Injury by Upregulating Expression of Transcription Factor Nrf2 and HO-1 in Rats
Junwei Ren et al.
NEUROCHEMICAL RESEARCH (2011)
Uptake, metabolism and toxicity of hemin in cultured neurons
Theresa N. Dang et al.
NEUROCHEMISTRY INTERNATIONAL (2011)
Modulation of pentylenetetrazole-induced kindling and oxidative stress by curcumin in mice
Nidhi Bharal Agarwal et al.
PHYTOMEDICINE (2011)
Metabolism and Tissue Distribution of Sulforaphane in Nrf2 Knockout and Wild-Type Mice
John D. Clarke et al.
PHARMACEUTICAL RESEARCH (2011)
Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2
Zoltan Ungvari et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2010)
Cancer Chemoprevention Mechanisms Mediated Through the Keap1-Nrf2 Pathway
John D. Hayes et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme
Zhang Ping et al.
BRAIN RESEARCH (2010)
Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies
Jenny Epstein et al.
BRITISH JOURNAL OF NUTRITION (2010)
Parental Occurrence of Stroke and Risk of Stroke in Their Children The Framingham Study
Sudha Seshadri et al.
CIRCULATION (2010)
Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study
Martin J. O'Donnell et al.
LANCET (2010)
Curcumin Improves Outcomes and Attenuates Focal Cerebral Ischemic Injury via Antiapoptotic Mechanisms in Rats
Jing Zhao et al.
NEUROCHEMICAL RESEARCH (2010)
Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
Deepti Malhotra et al.
NUCLEIC ACIDS RESEARCH (2010)
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
Michael McMahon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease
Gerasimos P. Sykiotis et al.
SCIENCE SIGNALING (2010)
Sulforaphane protects liver injury induced by intestinal ischemia reperfusion through Nrf2-ARE pathway
Hai-Dong Zhao et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2010)
Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
Chenhui Yang et al.
BRAIN RESEARCH (2009)
Protective Effects of Resveratrol and Quercetin Against MPP+ -Induced Oxidative Stress Act by Modulating Markers of Apoptotic Death in Dopaminergic Neurons
Julie Bournival et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2009)
Nrf2:INrf2 (Keap1) signaling in oxidative stress
James W. Kaspar et al.
FREE RADICAL BIOLOGY AND MEDICINE (2009)
Sulforaphane Protects Astrocytes Against Oxidative Stress and Delayed Death Caused by Oxygen and Glucose Deprivation
Camelia A. Danilov et al.
GLIA (2009)
Efficacy and safety of fumaric acid esters in the long-term treatment of psoriasis - A retrospective study (FUTURE)
Kristian Reich et al.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2009)
Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
Zheng Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Molecular mechanisms underlying cochlear degeneration in the tubby mouse and the therapeutic effect of sulforaphane
Li Kong et al.
NEUROCHEMISTRY INTERNATIONAL (2009)
Low Doses of Carbon Monoxide Protect Against Experimental Focal Brain Ischemia
Emil Zeynalov et al.
NEUROTOXICITY RESEARCH (2009)
Sex Differences in Stroke Epidemiology A Systematic Review
Peter Appelros et al.
STROKE (2009)
Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo:: Implications for the prevention of fetal alcohol spectrum disorders
Jian Dong et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat
Preeti Dohare et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats
Jing Zhao et al.
BRAIN RESEARCH (2008)
Multi-targeted prevention of cancer by sulforaphane
John D. Clarke et al.
CANCER LETTERS (2008)
Ischemic Neuronal Damage
Era Taoufik et al.
CURRENT PHARMACEUTICAL DESIGN (2008)
A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95® CG (Biocurcumax™), A Novel Bioenhanced Preparation of Curcumin
B. Antony et al.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)
Multiple nuclear localization signals function in the nuclear import of the transcription factor nrf2
Melanie Theodore et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
The transcription factor Nrf2 is a therapeutic target against brain inflammation
Nadia G. Innamorato et al.
JOURNAL OF IMMUNOLOGY (2008)
Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation
Genevieve Bureau et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2008)
Anti-ischemic effect of curcumin in rat brain
Pradeep K. Shukla et al.
NEUROCHEMICAL RESEARCH (2008)
Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke
Werner Hacke et al.
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Dose-response relationship between cigarette smoking and risk of ischemic stroke in young women
Viveca M. Bhat et al.
STROKE (2008)
Curcuma oil: Reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain
Priyanka Rathore et al.
NEUROCHEMICAL RESEARCH (2008)
Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation
Paul Talalay et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microglia
Eduardo Candelario-Jalil et al.
JOURNAL OF NEUROINFLAMMATION (2007)
Translational control of Nrf2 protein in activation of antioxidant response by oxidants
Sally E. Purdom-Dickinson et al.
MOLECULAR PHARMACOLOGY (2007)
Role of reactive oxygen species in modulation of Nrf2 following ischemic reperfusion injury
Z. A. Shah et al.
NEUROSCIENCE (2007)
Resveratrol inhibits nitric oxide and prostaglandin E2 production by lipopolysaccharide-activated C6 microglia
Young Ae Kim et al.
JOURNAL OF MEDICINAL FOOD (2007)
Neuroprotective effect of curcumin on focal cerebral ischemic rats by preventing blood-brain barrier damage
Jun Jiang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Chemoprotective and carcinogenic effects of tert-butylhydroquinone and its metabolites
Negar Gharavi et al.
CURRENT DRUG METABOLISM (2007)
Protective effect of resveratrol against oxygen-glucose deprivation in organotypic hippocampal slice cultures: Involvement of P13-K pathway
Lauren L. Zamin et al.
NEUROBIOLOGY OF DISEASE (2006)
Carbon monoxide-induced early thrombolysis contributes to heme oxygenase-1-mediated inhibition of neointimal growth after vascular injury in hypercholesterolemic mice
Yen-Hui Chen et al.
JOURNAL OF BIOMEDICAL SCIENCE (2006)
NAD(P)H:: quinone oxidoreductase 1 expression in multiple sclerosis lesions
Jack van Horssen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Fumaric acid esters are effective in chronic experimental autoimmune encephalomyelitis and suppress macrophage infiltration
S. Schilling et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2006)
Impaired glucose tolerance increases stroke risk in nondiabetic patients with transient ischemic attack or minor ischemic stroke
Sarah E. Vermeer et al.
STROKE (2006)
Effects of amelioration of total flavonoids from stems and leaves of Scutellaria baicalensis Georgi on cognitive deficits, neuronal damage and free radicals disorder induced by cerebral ischemia in rats
YZ Shang et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2006)
Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
CW Leffler et al.
JOURNAL OF APPLIED PHYSIOLOGY (2006)
Phospholipase A2, reactive oxygen species, and lipid peroxidation in cerebral ischemia
RM Adibhatla et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
J Zhao et al.
NEUROSCIENCE LETTERS (2006)
Prevention of cerebral oxidative injury by post-ischemic intravenous administration of Shengmai San
Haruyo Ichikawa et al.
AMERICAN JOURNAL OF CHINESE MEDICINE (2006)
The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation
P Nioi et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Sulforaphane enhances aquaporin-4 expression and decreases cerebral edema following traumatic brain injury
J Zhao et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo
AY Shih et al.
JOURNAL OF NEUROSCIENCE (2005)
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
CY Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Induction of quinone reductase by sulforaphane and sulforaphane N-acetylcysteine conjugate in murine hepatoma cells
ES Hwang et al.
JOURNAL OF MEDICINAL FOOD (2005)
Curcumin inhibits formation of amyloid β oligomers and fibrils, binds plaques, and reduces amyloid in vivo
FS Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative stress and neuronal death/survival signaling in cerebral ischemia
A Saito et al.
MOLECULAR NEUROBIOLOGY (2005)
Resveratrol inhibits nitric oxide and TNF-alpha production by lipopolysaccharide-activated microglia
XL Bi et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2005)
Monomethylfumarate affects polarization of monocyte-derived dendritic cells resulting in downregulated Th1 lymphocyte responses
NHR Litjens et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2004)
Neuroprotective effect of curcumin in middle cerebral artery occlusion induced focal cerebral ischemia in rats
M Thiyagarajan et al.
LIFE SCIENCES (2004)
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2
A Kobayashi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
In vivo pharmacokinetics and regulation of gene expression profiles by isothiocyanate sulforaphane in the rat
R Hu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Presystemic metabolism and intestinal absorption of antipsoriatic fumaric acid esters
D Werdenberg et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2003)
The role of lipid profile in determining the risk of ischemic stroke in the elderly: a case-control study
L Denti et al.
ARCHIVES OF GERONTOLOGY AND GERIATRICS (2003)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Curcurnin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
E Balogun et al.
BIOCHEMICAL JOURNAL (2003)
Dimethylfumarate is a potent inducer of apoptosis in human T cells
F Treumer et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2003)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain
AI Ghoneim et al.
PHARMACOLOGICAL RESEARCH (2002)
Dimethylfumarate inhibits TNF-induced nuclear entry of NF-κB/p65 in human endothelial cells
R Loewe et al.
JOURNAL OF IMMUNOLOGY (2002)
Carbon monoxide: Innovative anti-inflammatory properties of an age-old gas molecule
LE Otterbein
ANTIOXIDANTS & REDOX SIGNALING (2002)
Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
Y Katoh et al.
GENES TO CELLS (2001)
The antipsoriatic drug dimethylfumarate strongly suppresses chemokine production in human keratinocytes and peripheral blood mononuclear cells
TJ Stoof et al.
BRITISH JOURNAL OF DERMATOLOGY (2001)
Molecular mechanisms of calcium-dependent excitotoxicity
R Sattler et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2000)