Journal
MOLECULES
Volume 26, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/molecules26133980
Keywords
magnetic nanoparticles; molecularly imprinted polymer; magnetic hyperthermia; proteins; denaturation
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The study developed a facile and effective method to synthesize magnetic molecularly imprinted polymer nanoparticles for damaging proteins. The hybrid material showed high adsorption capacities and strong affinity, with the decrease in fluorescence intensity attributed to heat generated by an alternative magnetic field.
The inhibition of the protein function for therapeutic applications remains challenging despite progress these past years. While the targeting application of molecularly imprinted polymer are in their infancy, no use was ever made of their magnetic hyperthermia properties to damage proteins when they are coupled to magnetic nanoparticles. Therefore, we have developed a facile and effective method to synthesize magnetic molecularly imprinted polymer nanoparticles using the green fluorescent protein (GFP) as the template, a bulk imprinting of proteins combined with a grafting approach onto maghemite nanoparticles. The hybrid material exhibits very high adsorption capacities and very strong affinity constants towards GFP. We show that the heat generated locally upon alternative magnetic field is responsible of the decrease of fluorescence intensity.
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