Total Synthesis of Pagoamide A

The first total synthesis of the thiazole-containing cyclic depsipeptide pagoamide A, is detailed. The longest linear sequence of the liquid-phase synthesis comprises 9 long linear steps from simple known starting materials, which led to the unambiguous structural confirmation of pagoamide A.

Automated summary

The first total synthesis of thiazole-containing cyclic depsipeptide pagoamide A has been achieved through a 9-step liquid-phase synthesis from simple known starting materials, confirming its structure unambiguously.