APOE4-mediated Alzheimer disease and Vascular-Meningeal Lymphatic components: towards a novel therapeutic era?

A three-dimensional graphic design representation of the potential role of meningeal vessels in Alzheimer disease. Although there are major differences between APOE4(+) and APOE4(-) Alzheimer disease cases (described in detail in the Comment article by Mentis and colleagues), the figure depicts the clearance of macromolecules and other solutes from meningeal lymphatic vessels. Cover image: Ella Maru Studio.

Automated summary

The three-dimensional graphic design illustrates the potential role of meningeal vessels in Alzheimer disease, showing the clearance of solutes from meningeal lymphatic vessels. The image highlights differences between APOE4(+) and APOE4(-) Alzheimer disease cases outlined in the accompanying Comment article.