Journal
MOLECULAR PHARMACEUTICS
Volume 18, Issue 8, Pages 3171-3180Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.1c00400
Keywords
chronic wounds; multifunctional wound dressing; nanomedicine; endogenous repair
Funding
- BWH
- FEDER
- NSF [1945779]
- MINECO [MAT2016-80266-R]
- Xunta de Galicia [ED431E 2018/08, ED431C 2018/26]
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1945779] Funding Source: National Science Foundation
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A multifunctional wound dressing has been developed by the research team to target multiple challenges in wound healing, accelerating the healing process and representing a promising alternative to current products.
Current treatment of chronic wounds has been critically limited by various factors, including bacterial infection, biofilm formation, impaired angiogenesis, and prolonged inflammation. Addressing these challenges, we developed a multifunctional wound dressing-based three-pronged approach for accelerating wound healing. The multifunctional wound dressing, composed of nanofibers, functional nanoparticles, natural biopolymers, and selected protein and peptide, can target multiple endogenous repair mechanisms and represents a promising alternative to current wound healing products.
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