Journal
MOLECULAR NUTRITION & FOOD RESEARCH
Volume 65, Issue 16, Pages -Publisher
WILEY
DOI: 10.1002/mnfr.202100146
Keywords
depression; gut microbiota; neurotransmitter; partially hydrolyzed guar gum; short-chain fatty acids
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Funding
- Funds of Scientific Research-Support Project, Fujian Provincial Department of Finance [83020008]
- Funds of Joint Plan for Health Education in Fujian [WKJ2016-2-25]
- National Natural Science Foundation of China [81971837]
- Natural Science Foundation of Fujian Province, China [2020J05109]
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The study found that PHGG can effectively prevent and alleviate depression in mice induced by chronic stress, possibly through regulating the gut microbiota structure, increasing short-chain fatty acid levels, and enhancing serotonin and dopamine levels.
Scope Depression is the leading cause of disability around the world; however, most antidepressants have drug tolerance and serious side effects. In this study, it is explored whether partially hydrolyzed guar gum (PHGG) is a safe food that exhibits protection in a mouse model of depression. Methods and Results PHGG is orally administered to mice with depression induced by chronic unpredictable mild stress (CUMS) in two animal experiments (prevention trial and intervention trial) to characterize the potentially protective effect of PHGG. The results in the prevention trial show that PHGG significantly inhibits the loss of body weight, and prevents CUMS-induced depressive-like behavior in mice. The beneficial effects may be associated with PHGG modulating the gut microbiota structure and then increasing the levels of short-chain fatty acids in mice feces and the levels of 5-hydroxytryptamine and dopamine in serum, striatum, and hippocampus. Besides, PHGG in the intervention trial is less effective than that in the prevention trial, but it may have a synergistic effect on improving depression with fluoxetine. Conclusions This study suggests that moderate daily intake of PHGG can contribute to relieving depressive-like behavior.
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