4.5 Review

Bacterial approaches to sensing and responding to respiration and respiration metabolites

Journal

MOLECULAR MICROBIOLOGY
Volume 116, Issue 4, Pages 1009-1021

Publisher

WILEY
DOI: 10.1111/mmi.14795

Keywords

cell respiration; genetic regulation; oxidation-reduction; quinone; transcription

Funding

  1. U.S. Department of Agriculture [NE1028]
  2. National Institute of Allergy and Infectious Diseases [1R01AI139100-01]

Ask authors/readers for more resources

Bacterial respiration of diverse substrates is a key contributor to life diversity, driving changes in the geosphere and connecting ecological nodes. Organisms utilize respiration to dissipate reductants and generate energy, with mechanisms evolved to sense and regulate the utilization of respiration substrates for cellular health.
Bacterial respiration of diverse substrates is a primary contributor to the diversity of life. Respiration also drives alterations in the geosphere and tethers ecological nodes together. It provides organisms with a means to dissipate reductants and generate potential energy in the form of an electrochemical gradient. Mechanisms have evolved to sense flux through respiratory pathways and sense the altered concentrations of respiration substrates or byproducts. These genetic regulatory systems promote efficient utilization of respiration substrates, as well as fine-tune metabolism to promote cellular fitness and negate the accumulation of toxic byproducts. Many bacteria can respire one or more chemicals, and these regulatory systems promote the prioritization of high-energy metabolites. Herein, we focus on regulatory paradigms and discuss systems that sense the concentrations of respiration substrates and flux through respiratory pathways. This is a broad field of study, and therefore we focus on key fundamental and recent developments and highlight specific systems that capture the diversity of sensing mechanisms.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.5
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available