Journal
BRITISH JOURNAL OF CANCER
Volume 112, Issue 4, Pages 739-744Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2015.1
Keywords
ovarian cancer; high-grade serous adenocarcinoma; platinum sensitivity; high-temperature-required protein A2 (HtrA2)
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Funding
- Grants-in-Aid for Scientific Research [15H04315] Funding Source: KAKEN
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Background: High-temperature-required protein A2 (HtrA2), a protein relating with apoptosis in a caspases-dependent and non-dependent manner, has been reported to be associated with chemosensitivity in several human cancers. Methods: Tissue microarrays made from 142 patients with high-grade serous ovarian adenocarcinoma were evaluated to assess whether HtrA2 expression was related with several clinical parameters. Results: Negative HtrA2 expression was observed in 36 cases (25%) of the patients, and related with significantly lower response rates of primary chemotherapy than those with positive HtrA2 expression (56% vs 83%, P<0.01). In addition, negative HtrA2 expression was identified as an independent worse prognostic factor for progression-free survival and overall survival by multivariate analyses. Furthermore, HtrA2 downregulation modulated sensitivity to platinum in serous ovarian cancer cells in vitro. Conclusions: HtrA2 expression was a predictor for sensitivity to chemotherapy, and could be a candidate of molecular target in the treatment of high-grade serous ovarian cancers.
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