Journal
MOLECULAR MEDICINE
Volume 27, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s10020-021-00353-9
Keywords
Atherosclerosis; IL-22; Inflammatory response; Cytokine; Cholesterol metabolism
Funding
- Hunan Province Technology Innovation Guidance Program-Clinical Medical Technology Innovation Guidance Project [2018SK50410]
Ask authors/readers for more resources
IL-22 is a key player in the development of atherosclerosis, as it regulates various processes such as VSMC proliferation and migration, angiogenesis, inflammatory response, hypertension, and cholesterol metabolism, through its downstream signaling pathways. Its role in atherosclerosis pathogenesis makes it a potential therapeutic target for treating the disease.
Background Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids in the vascular wall. In this review, we focus on the latest advance regarding the regulation and signaling pathways of IL-22 and highlight its impacts on atherosclerosis. Main body IL-22, an important member of the IL-10 family of cytokines, is released by cells of the adaptive and innate immune system and plays a key role in the development of inflammatory diseases. The binding of IL-22 to its receptor complex can trigger a diverse array of downstream signaling pathways, in particular the JAK/STAT, to induce the expression of chemokines and proinflammatory cytokines. Recently, numerous studies suggest that IL-22 is involved in the pathogenesis of atherosclerosis by regulation of VSMC proliferation and migration, angiogenesis, inflammatory response, hypertension, and cholesterol metabolism. Conclusion IL-22 promotes the development of atherosclerosis by multiple mechanisms, which may be a promising therapeutic target in the pathogenesis of atherosclerosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available