Supply and demand: Cellular nutrient uptake and exchange in cancer

Nutrient supply and demand delineate cell behavior in health and disease. Mammalian cells have developed multiple strategies to secure the necessary nutrients that fuel their metabolic needs. This is more evident upon disruption of homeostasis in conditions such as cancer, when cells display high proliferation rates in energetically challenging conditions where nutritional sources may be scarce. Here, we summarize the main routes of nutrient acquisition that fuel mammalian cells and their implications in tumorigenesis. We argue that the molecular mechanisms of nutrient acquisition not only tip the balance between nutrient supply and demand but also determine cell behavior upon nutrient limitation and energetic stress and contribute to nutrient partitioning and metabolic coordination between different cell types in inflamed or tumorigenic environments.

Automated summary

Nutrient supply and demand play a crucial role in shaping cell behavior in health and disease, with mammalian cells employing various strategies to obtain necessary nutrients for metabolic needs. Disruption of homeostasis, as seen in conditions like cancer, can lead to increased proliferation rates in energetically challenging environments where nutrient sources are limited.