Journal
MOLECULAR BIOLOGY REPORTS
Volume 48, Issue 5, Pages 4625-4635Publisher
SPRINGER
DOI: 10.1007/s11033-021-06400-2
Keywords
Acute exercise; Neutrophil extracellular traps; Inflammation; Chronic exercise
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Funding
- Coordenadoria de Aperfeicoamento do Pessoal de Nivel Superior (CAPES)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG)
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This study reveals the significant connection between physical exercise, obesity, and NETs through bioinformatics analysis, indicating that physical training has a significant regulatory effect on NETs release and could be a therapeutic target for modulating inflammation.
Neutrophil extracellular traps (NETs) represent an innate organism defense mechanism characterized by neutrophil release of intracellular material to capture any aggressor agent. Elevated NETs release is associated with increased inflammatory response and related diseases, such as obesity. Chronic physical training is one of the main strategies to treat and prevent obesity. The relationship between physical training and NETs is still under study. The present review, followed by a bioinformatics analysis, demonstrates the meaningful connection between physical exercise, obesity, and NETs. The bioinformatics indicated TNF-alpha as a leading gene after the ontological analysis followed by positive-interleukin-6 regulation, chemokines, and inflammatory response regulation. The main results pointed to a relevant regulatory effect of physical training on NETs release, indicating physical exercise as a possible therapeutic target on modulating NETs and inflammation.
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