Journal
MOLECULAR AND CELLULAR BIOCHEMISTRY
Volume 476, Issue 10, Pages 3857-3867Publisher
SPRINGER
DOI: 10.1007/s11010-021-04192-4
Keywords
Myocardial infarction; Cardioprotection; Remote ischemic preconditioning
Categories
Funding
- National Agency for Scientific and Technological Promotion [ANPCyT] [PICT 2017-1447]
- University of Buenos Aires [UBACYT 20020150100105BA]
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Remote ischemic preconditioning (rIPC) can protect the heart from ischemia/reperfusion injury by activating different signaling pathways. Factors such as age, comorbidities, medication, and anesthetic protocol may weaken the subcellular mechanisms of rIPC in patients. Further carefully designed studies are necessary to develop a clearer understanding of the pathways and mechanisms of early and late rIPC.
Remote ischemic preconditioning (rIPC) is a cardioprotective phenomenon where brief periods of ischemia followed by reperfusion of one organ/tissue can confer subsequent protection against ischemia/reperfusion injury in other organs, such as the heart. It involves activation of humoral, neural or systemic communication pathways inducing different intracellular signals in the heart. The main purpose of this review is to summarize the possible mechanisms involved in the rIPC cardioprotection, and to describe recent clinical trials to establish the efficacy of these strategies in cardioprotection from lethal ischemia/reperfusion injury. In this sense, certain factors weaken the subcellular mechanisms of rIPC in patients, such as age, comorbidities, medication, and anesthetic protocol, which could explain the heterogeneity of results in some clinical trials. For these reasons, further studies, carefully designed, are necessary to develop a clearer understanding of the pathways and mechanism of early and late rIPC. An understanding of the pathways is important for translation to patients.
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