4.6 Article

MicroRNAs as biomarkers and perspectives in the therapy of pancreatic cancer

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

MiRNAs directly targeting the key intermediates of biological pathways in pancreatic cancer

Ammar Sarwar et al.

Summary: Pancreatic Cancer is a severe form of malignancy with delayed diagnosis and chemoresistance contributing to its poor prognosis. Recent research has categorized miRNAs targeting potential onco-factors in major cancer-related pathways, providing insights into early diagnostic and therapeutic interventions. This approach aims to understand the interaction of various miRNAs and develop a multifactorial treatment strategy for difficult-to-treat PC.

BIOCHEMICAL PHARMACOLOGY (2021)

Article Oncology

MiRNA-3662 reverses the gemcitabine resistance in pancreatic cancer through regulating the tumor metabolism

An Liu et al.

Summary: This study found that miRNA-3662 is down-regulated in PDAC clinical samples and cell lines. Functional experiments demonstrate that miRNA-3662 can inhibit Gem resistance in PDAC cells both in vitro and in vivo. Mechanistically, hypoxia-inducible factor 1alpha (HIF-1alpha) is identified as a transcriptional target of miRNA-3662 and is up-regulated in PDAC samples.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

Improving Gemcitabine Sensitivity in Pancreatic Cancer Cells by Restoring miRNA-217 Levels

Concetta Panebianco et al.

Summary: miR-217 enhances the sensitivity of pancreatic cancer cells to gemcitabine by impairing cell cycle progression, as shown in this study.

BIOMOLECULES (2021)

Article Medicine, Research & Experimental

Serum miR-210-3p can be used to differentiate between patients with pancreatic ductal adenocarcinoma and chronic pancreatitis

Malgorzata Guz et al.

Summary: This study investigated the potential use of miRNAs in differentiating between chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), finding that miR-210-3p may serve as a biomarker for distinguishing patients with PDAC from those with CP.

BIOMEDICAL REPORTS (2021)

Article Public, Environmental & Occupational Health

Cancer statistics: a comparison between World Health Organization (WHO) and Global Burden of Disease (GBD)

Camilla Mattiuzzi et al.

EUROPEAN JOURNAL OF PUBLIC HEALTH (2020)

Article Medicine, Research & Experimental

The Effect of Gemcitabine on Cell Cycle Arrest and microRNA Signatures in Pancreatic Cancer Cells

Daisuke Namima et al.

IN VIVO (2020)

Review Biochemistry & Molecular Biology

The plasticity of pancreatic cancer metabolism in tumor progression and therapeutic resistance

Douglas E. Biancur et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)

Article Oncology

Personalized RNA Medicine for Pancreatic Cancer

Maud-Emmanuelle Gilles et al.

CLINICAL CANCER RESEARCH (2018)

Review Oncology

microRNA based prognostic biomarkers in pancreatic Cancer

Shixiang Guo et al.

BIOMARKER RESEARCH (2018)

Review Immunology

MicroRNAs in pancreatic cancer diagnosis and therapy

Robert Slotwinski et al.

CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Review Biochemistry & Molecular Biology

Molecular Drivers of Pancreatic Cancer Pathogenesis: Looking Inward to Move Forward

Mohammad Aslam Khan et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

MicroRNA Targeted Therapeutic Approach for Pancreatic Cancer

Yiwei Li et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)

Article Gastroenterology & Hepatology

Molecular subtypes of pancreatic cancer based on miRNA expression profiles have independent prognostic value

Junghyun Namkung et al.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2016)

Review Oncology

Pancreatic cancer biology and genetics from an evolutionary perspective

Alvin Makohon-Moore et al.

NATURE REVIEWS CANCER (2016)

Review Pharmacology & Pharmacy

Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer

Satyanarayana Rachagani et al.

ADVANCED DRUG DELIVERY REVIEWS (2015)

Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

p53, a translational regulator: contribution to its tumour-suppressor activity

V. Marcel et al.

ONCOGENE (2015)

Article Gastroenterology & Hepatology

Peroxiredoxin 1 Promotes Pancreatic Cancer Cell Invasion by Modulating p38 MAPK Activity

Keisuke Taniuchi et al.

PANCREAS (2015)

Article Multidisciplinary Sciences

Ras-GTP dimers activate the Mitogen-Activated Protein Kinase (MAPK) pathway

Xiaolin Nan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Review Biochemistry & Molecular Biology

Structural determinants of Smad function in TGF-β signaling

Maria J. Macias et al.

TRENDS IN BIOCHEMICAL SCIENCES (2015)

Article Oncology

Circulating miR-483-3p and miR-21 is highly expressed in plasma of pancreatic cancer

Makoto Abue et al.

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

Article Genetics & Heredity

Global population-specific variation in miRNA associated with cancer risk and clinical biomarkers

Renata A. Rawlings-Goss et al.

BMC MEDICAL GENOMICS (2014)

Review Cell Biology

Regulation of microRNA biogenesis

Minju Ha et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Surgery

MicroRNA expression profiling of diagnostic needle aspirates from surgical pancreatic cancer specimens

Tae Ho Hong et al.

ANNALS OF SURGICAL TREATMENT AND RESEARCH (2014)

Article Oncology

miR-320c regulates gemcitabine-resistance in pancreatic cancer via SMARCC1

Y. Iwagami et al.

BRITISH JOURNAL OF CANCER (2013)

Article Oncology

miRNA profiling in pancreatic cancer and restoration of chemosensitivity

Saurabh Singh et al.

CANCER LETTERS (2013)

Review Medical Laboratory Technology

miRNA in clinical practice: Pancreatic cancer

Marine Humeau et al.

CLINICAL BIOCHEMISTRY (2013)

Article Pharmacology & Pharmacy

Prospects of miRNA-Based Therapy for Pancreatic Cancer

Priya Pai et al.

CURRENT DRUG TARGETS (2013)

Review Oncology

Diagnostic, prognostic, and predictive biomarkers in pancreatic cancer

Jordan M. Winter et al.

JOURNAL OF SURGICAL ONCOLOGY (2013)

Article Biochemistry & Molecular Biology

miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death

Zhiyu Chen et al.

MOLECULAR CANCER (2013)

Review Cell Biology

Control of cell cycle transcription during G1 and S phases

Cosetta Bertoli et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism

Haoqiang Ying et al.

Article Gastroenterology & Hepatology

miR-17-5p Inhibitor Enhances Chemosensitivity to Gemcitabine Via Upregulating Bim Expression in Pancreatic Cancer Cells

Hai-jiao Yan et al.

DIGESTIVE DISEASES AND SCIENCES (2012)

Review Medicine, Research & Experimental

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review

Marilena V. Iorio et al.

EMBO MOLECULAR MEDICINE (2012)

Article Medicine, Research & Experimental

Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

Meredith A. Collins et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Gastroenterology & Hepatology

Biological and Prognostic Relevance of Mitogen-Activated Protein Kinases in Pancreatic Adenocarcinoma

Adriana Handra-Luca et al.

PANCREAS (2012)

Article Multidisciplinary Sciences

Metastatic Pancreatic Cancer Is Dependent on Oncogenic Kras in Mice

Meredith A. Collins et al.

PLOS ONE (2012)

Article Genetics & Heredity

miR-34 – a microRNA replacement therapy is headed to the clinic

Andreas G. Bader

Frontiers in Genetics (2012)

Article Biochemistry & Molecular Biology

miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

Jong-Kook Park et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2011)

Article Surgery

Analyzing miRNAs in Ductal Adenocarcinomas of the Pancreas

Soeren Torge Mees et al.

JOURNAL OF SURGICAL RESEARCH (2011)

Review Oncology

Serum CA 19-9 as a Biomarker for Pancreatic Cancer-A Comprehensive Review

Umashankar K. Ballehaninna et al.

INDIAN JOURNAL OF SURGICAL ONCOLOGY (2011)

Article Medical Laboratory Technology

MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions

Mael Chalret du Rieu et al.

CLINICAL CHEMISTRY (2010)

Article Chemistry, Multidisciplinary

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

Douglas D. Young et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Article Multidisciplinary Sciences

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

Shinichi Yachida et al.

NATURE (2010)

Article Oncology

MicroRNA miR-155 is a biomarker of early pancreatic neoplasia

Nils Habbe et al.

CANCER BIOLOGY & THERAPY (2009)

Article Gastroenterology & Hepatology

Retinoic Acid Receptor Antagonists Inhibit miR-10a Expression and Block Metastatic Behavior of Pancreatic Cancer

Frank Ulrich Weiss et al.

GASTROENTEROLOGY (2009)

Review Genetics & Heredity

Causes and consequences of microRNA dysregulation in cancer

Carlo M. Croce

NATURE REVIEWS GENETICS (2009)

Article Biochemistry & Molecular Biology

Potent inhibition of microRNA in vivo without degradation

Scott Davis et al.

NUCLEIC ACIDS RESEARCH (2009)

Article Multidisciplinary Sciences

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

Qing Ji et al.

PLOS ONE (2009)

Article Chemistry, Multidisciplinary

Small-molecule inhibitors of microRNA miR-21 function

Kiranmai Gumireddy et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)

Article Biochemical Research Methods

Inhibition of microRNA with antisense oligonucleotides

Christine C. Esau

METHODS (2008)

Article Multidisciplinary Sciences

Circulating microRNAs as stable blood-based markers for cancer detection

Patrick S. Mitchell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Medicine, General & Internal

MicroRNA expression patterns to differentiate pancreatic adenocarcinoma from normal pancreas and chronic pancreatitis

Mark Bloomston et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2007)

Article Oncology

Expression profiling identifies microRNA signature in pancreatic cancer

Eun Jon Lee et al.

INTERNATIONAL JOURNAL OF CANCER (2007)

Review Developmental Biology

microRNAs as oncogenes and tumor suppressors

Baohong Zhang et al.

DEVELOPMENTAL BIOLOGY (2007)

Article Cell Biology

Epigenetic activation of tumor suppressor microRNAs in human cancer cells

Yoshimasa Saito et al.

CELL CYCLE (2006)

Article Biochemistry & Molecular Biology

Improved targeting of miRNA with antisense oligonucleotides

Scott Davis et al.

NUCLEIC ACIDS RESEARCH (2006)

Article Multidisciplinary Sciences

Silencing of microRNAs in vivo with 'antagomirs'

J Krützfeldt et al.

NATURE (2005)

Article Multidisciplinary Sciences

MicroRNA expression profiles classify human cancers

J Lu et al.

NATURE (2005)

Review Gastroenterology & Hepatology

Surgery for pancreatic cancer: Recent controversies and current practice

CJ Wray et al.

GASTROENTEROLOGY (2005)

Review Cell Biology

MicroRNA biogenesis: Coordinated cropping and dicing

VN Kim

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Review Cell Biology

Ras redux: rethinking how and where Ras acts

SR Hingorani et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2003)

Review Oncology

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

PM Siegel et al.

NATURE REVIEWS CANCER (2003)

Article Multidisciplinary Sciences

Surfing the p53 network

B Vogelstein et al.

NATURE (2000)