Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 245, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molbiopara.2021.111412
Keywords
Schistosoma mansoni; fs800; Eggs; Schistosomiasis; RNAi
Categories
Funding
- NIH-NCI [P30 CA54174]
- SABER IRACDA [2k12GM111726]
- NIH [NIAIDAI27219]
- UT Health San Antonio
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A newly discovered gene fs800 plays a crucial role in egg production of female Schistosoma mansoni, suggesting its inhibition as a potential target to prevent the transmission and pathology of schistosomiasis.
During schistosomiasis, the paired Schistosoma mansoni female produces about 300 eggs each day. These eggs are responsible for the clinical picture and the transmission of the disease. During female development and egg production, fs800 is expressed only in female vitelline cells. Blast search of fs800 did not show similarities with any published sequences by NCBI. We hypothesize that the product of this gene plays a role in S. mansoni egg production. By using RNA interference to knockdown fs800 and quantitative PCR to measure the gene expression in the female schistosomes, we were able to demonstrate that fs800 product is crucial for viable egg production, it has no effect on worm health or male-female pairing. Our data suggest fs800 inhibition as a potential target to prevent transmission and pathology of schistosomiasis.
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