4.7 Article

Deep eutectic solvent synthesis of iron vanadate-decorated sulfur-doped carbon nanofiber nanocomposite: electrochemical sensing tool for doxorubicin

Journal

MICROCHIMICA ACTA
Volume 188, Issue 9, Pages -

Publisher

SPRINGER WIEN
DOI: 10.1007/s00604-021-04950-7

Keywords

Electrocatalyst; Transition metal-vanadate; Anticancer drug; S-doped carbon nanofibers; Deep eutectic solvent synthesis

Funding

  1. National Taipei University of Technology [MOST 107-2113-M-027-005 MY3]
  2. Ministry of Science and Technology, Taiwan

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An electrochemical sensor for detecting anticancer drug using a transition metal vanadate's related carbon composite material has been developed, showing improved efficiency and wide detection range. The sensor exhibits high sensitivity and enhanced selectivity even in the presence of common interferents, making it suitable for real-time applications.
Detection of anticancer drug (doxorubicin) using an electrochemical sensor is developed based on a transition metal vanadate's related carbon composite material. With an environmentally friendly process, we have synthesized a metal oxide composite of iron vanadate nanoparticle assembled with sulfur-doped carbon nanofiber (FeV/SCNF). The FeV/SCNF composite was characterized using XRD, TEM, FESEM with elemental mapping, XPS and EDS. In contrast to other electrodes reported in the literature, a much-improved electrochemical efficiency is shown by FeV/SCNF composite modified electrodes. Amperometric technique has been employed at 0.25 V (vs. Ag/AgCl) for the sensitive detection of DOX within a wide range of 20 nM-542.5 mu M and it possesses enhanced selectivity in presence of common interferents. The modified electrochemical sensors show high sensitivity of 46.041 mu A mu M-1 cm(-2). The newly developed sensor could be used for the determination of doxorubicin in both blood serum and drug formulations with acceptable results, suggesting its feasibility for real-time applications.

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