Journal
MICROBIOLOGICAL RESEARCH
Volume 247, Issue -, Pages -Publisher
ELSEVIER GMBH
DOI: 10.1016/j.micres.2021.126725
Keywords
Glucose; Virulence; Pathogenicity; Candida albicans; Aspergillus; Cryptococcus; Fungal infections
Categories
Funding
- Department of Science and Technology (DST)-GoI under INSPIRE Faculty Award [DST/INSPIRE/04/2015/001575]
- Science and Engineering Research Board (SERB)-GoI under Early Career Research Award [ECR/2016/000463]
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The incidence of human fungal infections is increasing due to the expansion of the immunocompromised patient population. Fungal pathogens deploy multiple resistance strategies to tackle the effect of antifungal agents, with glucose playing a central role in influencing pathogenicity and virulence traits.
The incidence of human fungal infections is increasing due to the expansion of the immunocompromised patient population. The continuous use of different antifungal agents has eventually resulted in the establishment of resistant fungal species. The fungal pathogens unfold multiple resistance strategies to successfully tackle the effect of different antifungal agents. For the successful colonization and establishment of infection inside the host, the pathogenic fungi switch to the process of metabolic flexibility to regulate distinct nutrient uptake systems as well as to modulate their metabolism accordingly. Glucose the most favourable carbon source helps carry out the important survival and niche colonization processes. Adopting glucose as the center, this review has been put forward to provide an outline of the important processes like growth, the progression of infection, and the metabolism regulated by glucose, affecting the pathogenicity and virulence traits in the human pathogenic fungi. This could help in the identification of better treatment options and appropriate target-oriented antifungal drugs based on the glucose-regulated pathways and processes. In the article, we have also presented a summary of the novel studies and findings pointing to glucose-based potential therapeutic avenues to be explored to tackle the problem of globally increasing multidrug-resistant human fungal infections.
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