Association between thyroid function and Alzheimer's disease: A systematic review

Alterations in metabolic parameters have been associated with an increased risk of dementia, among which thyroid function has gained great importance in Alzheimer's disease (AD) pathology in recent years. However, it remains unclear whether thyroid dysfunctions could influence and contribute to the beginning and/or progression of AD or if it results from AD. This systematic review was conducted to examine the association between thyroid hormone (TH) levels and AD. Medline, ISI Web of Science, EMBASE, Cochrane library, Scopus, Scielo, and LILACS were searched, from January 2010 to March 2020. A total of 17 articles were selected. The studies reported alterations in TH and circadian rhythm in AD patients. Behavior, cognition, cerebral blood flow, and glucose consumption were correlated with TH deficits in AD patients. Whether thyroid dysfunctions and AD have a cause-effect relationship was inconclusive, however, the literature was able to provide enough data to corroborate a relationship between TH and AD. Although further studies are needed in this field, the current systematic review provides information that could help future investigations.

Automated summary

Studies have shown alterations in TH and circadian rhythm in AD patients, with TH deficits correlated with behavior, cognition, cerebral blood flow, and glucose consumption. The causal relationship between thyroid dysfunctions and AD remains inconclusive, but there is enough evidence in the literature to support a relationship between TH and AD. Further research in this field is needed to better understand the potential impact of TH on AD.