Journal
MEDICINE
Volume 100, Issue 25, Pages -Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MD.0000000000026453
Keywords
protocol; recombinant tissue plasminogen activator; small artery occlusion; stroke; thrombolysis
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Funding
- Shandong Science and Technology Bureau [48596023]
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The study aims to investigate the efficacy and safety of intravenous thrombolysis with rt-PA in SAO-patients through meta-analysis, finding that rt-PA may be effective and safe for this patient population.
Background: Recent observations raised concern that the intravenous recombinant tissue plasminogen activator (rt-PA) may result in damage to stroke patients caused by small artery occlusion (SAO). Thus, we perform a protocol for meta-analysis to investigate the efficacy and safety of intravenous thrombolysis with rt-PA in SAO-patients. Methods: The search-style electronic libraries, including Pubmed, Embase, the Cochrane Library, Web of Science, Wanfang Data, VIP Chinese Journals, and China Biomedical Literature Service System are used for document retrieval in June 2021 with no restrictions on language. The risk of bias in include articles will be assessed using the Cochrane Risk of Bias Tool. We perform the meta-analysis by Stata version 10.0 software and calculated the statistics using the inverse variance statistical method. Binary outcomes are presented as Mantel-Haenszel-style risk ratios with 95% confidence interval. Continuous outcomes are reported as mean differences. Results: The results of the article will be shown in a peer-reviewed journal. Conclusion: Intravenous rt-PA may be effective and safe in SAO-patients.
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