Journal
MEDICINA CLINICA
Volume 158, Issue 7, Pages 308-314Publisher
ELSEVIER ESPANA SLU
DOI: 10.1016/j.medcli.2021.04.027
Keywords
Diabetic microangiopathy; Type 2 Diabetes Mellitus; Trabecular bone score; 25-hydroxyvitamin D; Vitamin D deficiency; Bone metabolic diseases
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This study found an association between diabetic microvascular disease and bone fragility in type 2 diabetic patients. Additionally, a relationship was observed between vitamin D levels and microvascular disease.
Background and objective: Diabetic microvascular disease (MVD) has been associated with increased bone fragility. The objective was to analyse the relationship between MVD and trabecular microstructure - assessed by the trabecular bone score (TBS)- in type 2 diabetic (T2D) patients. A second aim was to know the relationship between vitamin D and MVD. Patients and methods: Cross-sectional study, which included men >50 years and postmenopausal women participating in a population-based cohort, diagnosed with T2D. The presence of nephropathy, neuropathy and/or retinopathy was classified as MVD+. Clinical and laboratory variables, TBS, 25(OH)D and BMD by DXA, were evaluated. Bivariate and multivariate analysis were performed. Results: We evaluated 361 patients (51.1% women), 63.8 (9) years old. Of them, 92 were MVD+ and presented poorer metabolic control, longer duration of T2D, lower TBS [1.235 (.1) vs. 1.287 (.1); p = .007] and lower levels of 25(OH)D [18.3 (7) vs. 21.6 (8) ng/ml; p = .0001). There were no differences between MVD+ and MVD- with regard to BMD or P1NP and beta-CTX markers. After adjusting for confounders, including HbA1c and duration of T2D, the TBS value in MVD+ was 1.252 (95% CI 1.230-1.274) vs. 1.281 (95% CI 1.267-1.295) in MVD- (p = .034). MVD was associated with a 25(OH)D level <20 ng ml with an adjusted OR of 1.88 (95% CI 1.06-3.31; p = .028). Conclusions: The MVD+ patients presented a significantly lower TBS, after adjusting for confounders. Furthermore, multivariable analysis showed a significant relationship between a low 25(OH)D level and a prevalent MVD. (C) 2021 Elsevier Espana, S.L.U. All rights reserved.
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