Journal
FRONTIERS IN NEUROENDOCRINOLOGY
Volume 41, Issue -, Pages 3-22Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2016.03.003
Keywords
Neurogenesis; Songbird; Canary; HVC; BrdU; Endogenous marker of neurogenesis; Doublecortin
Categories
Funding
- NIH [NINDS RO1 35467]
- Interuniversity Attraction Pole of the Belgian Science Policy Office (BELSPO) [SSTC PAI P7/17]
Ask authors/readers for more resources
The identification of pronounced seasonal changes in the volume of avian song control nuclei stimulated the discovery of adult neurogenesis in songbirds as well as renewed studies in mammals including humans. Neurogenesis in songbirds is modulated by testosterone and other factors such as photoperiod, singing activity and social environment. Adult neurogenesis has been widely studied by labeling, with tridated thymidine or its analog BrdU, cells duplicating their DNA in anticipation of their last mitotic division and following their fate as new neurons. New methods based on endogenous markers of cell cycling or of various stages of neuronal life have allowed for additional progress. In particular immunocytochemical visualization of the microtubule-associated protein doublecortin has provided an integrated view of neuronal replacement in the song control nucleus HVC. Multiple questions remain however concerning the specific steps in the neuronal life cycle that are modulated by various factors and the underlying cellular mechanisms. (C) 2016 Published by Elsevier Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available