Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 125, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112083
Keywords
Calcium carbonate; Silver nanoparticle; Ultrasonic spray-pyrolysis technique; Antibacterial property; Cytotoxicity
Categories
Funding
- New Energy and Industrial Technology Development Organization (NEDO)
- International Research Fellows of Japan Society for the Promotion of Science (Postdoctoral Fellowships for Research in Japan)
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This study successfully prepared silver nanoparticles loaded calcium carbonate through ultrasonic spray-pyrolysis route, achieving effective antibacterial efficiency against Staphylococcus aureus and Escherichia coli, while also supporting osteoblast-like cell growth.
Calcium carbonate is used as bone-filling material due to its good biocompatibility, bioactivity, and bioabsorbability, but the prevalence of infectious complications associated with calcium carbonate has created a persisting challenge in the treatment of bone defect. Therefore, this greatly necessitate the need to endow calcium carbonate with antibacterial properties. In this study, calcium carbonate powders loaded with silver nanoparticles (Ag-CaCO3) were prepared in attempt to serve as a novel antibacterial inorganic filler material. This objective was achieved using ultrasonic spray-pyrolysis (USSP) route to produce Ag-CaCO3 with 1, 5 and 10 mol% silver. The size of silver nanoparticles on CaCO3 microspheres could be regulated by adjusting silver concentration to facilitate effective release of Ag+ ions. This was demonstrated in Ag-CaCO3 (1), where the lowest silver content at 1 mol% achieved the highest Ag+ ions release over 28 days. This in turn gave rise to effective antibacterial efficiency against Staphylococcus aureus and Escherichia coli. Furthermore, CaCO3 (1) could also support osteoblast-like cells (MG-63) at a cell viability of 80%. Overall, this work extends the capabilities in employing USSP to produce inorganic filler materials with sustained antibacterial properties, bringing one step closer to the development of antibacterial products.
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