Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 127, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112245
Keywords
Curcumin; Sandwich-like nanofibrous membrane; Hemostasis; Antibacterial; Wound healing
Categories
Funding
- Open Foundation of the State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process [SKL2020Z0208]
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This study demonstrated that the prepared CSNM membrane has good hemostatic, antibacterial, and wound healing promoting effects. Through experiments and models, it showed its multifunctionality and promotion of various stages of wound healing.
Wound healing is a complicated process constituted of four successive physiological stages involving wound bleeding, inflammatory response, cell proliferation and tissue remodeling. During this period, bacteria can easily infect the wound. Therefore, we prepared a novel curcumin-loaded sandwich-like nanofibrous membrane (CSNM) using sequential electrospinning for the hemostasis, antibacterial and accelerate wound healing. The morphology of the nanofibrous membrane was analyzed by SEM. In addition, the water absorption capacity, water vapor transmission rate, water contact-angle, and in vitro drug release were all tested. Then in vitro and in vivo hemostatic experiments demonstrated that CSNM has a good hemostatic effect. Antioxidant effect was assessed by the DPPH radical scavenging method and CSNM presented a high antioxidant activity. Additionally, CSNM demonstrated excellent antibacterial activity by the disk diffusion method. Furthermore, the rat dorsal skin defects model revealed that the CSNM distinctly induced the granulation tissue grew, collagen deposition and epithelial tissue remodeling. Meanwhile, the results of the immunohistochemical staining showed that the CSNM can facilitate the expression of CD31 and TGF-beta in the early stage of the wound, thereby accelerating wound healing. In general, this study proved that the multifunctional CSNM has great potential as wound dressing in wound healing.
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