Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 126, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.msec.2021.112123
Keywords
Baicalin; Ischemic stroke; Exosomes; Neuroprotection; Reactive oxygen species
Categories
Funding
- National Natural Science Foundation of China [81971231]
- Project of Liaoning Educational Committee [JYTJCZR2020067]
- Xingliao Yingcai Project Foundation of Liaoning Province [XLYC1907178]
- Natural Science Foundation of Liaoning Province [2019ZD0808]
Ask authors/readers for more resources
Novel brain-targeted BA-loaded macrophage-derived exosomes (Exo-BA) were designed to induce neuroprotection against ischemic stroke in animal models, showing significantly enhanced solubility and better brain targeting ability than free BA. Exo-BA also reduced the generation of reactive oxygen species (ROS) and activated the Nrf2/HO-1 pathway in neurons, thus alleviating cerebral ischemic injury in a stroke model.
Baicalin (BA), a strong free radical scavenger, has been demonstrated to exert neuroprotective effects in the treatment of ischemic stroke. However, its clinical application has been limited due to its inability to target the brain and its poor solubility. In this study, we designed novel brain-targeted BA-loaded macrophage-derived exosomes (Exo-BA) to induce neuroprotection against ischemic stroke in animal models. The results revealed that with the help of Exo, the solubility of BA was significantly enhanced. In addition, Exo-BA displayed better brain targeting ability than free BA, as they induced the transfer of more BA into the brain, in a transient middle cerebral artery occlusion/reperfusion (tMCAO) model and permanent middle cerebral artery occlusion (pMCAO) model. Compared with free BA, Exo-BA significantly reduced the generation of reactive oxygen species (ROS) and activated the Nrf2/HO-1 pathway in neurons, thus significantly alleviating cerebral ischemic injury in a stroke model.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available