Journal
BRITISH JOURNAL OF CANCER
Volume 113, Issue 5, Pages 729-737Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/bjc.2015.242
Keywords
glioblastoma; IGF-IR; immunohistochemistry; biomarker; prognosis
Categories
Funding
- 'Fonds National de la Recherche Scientifique'
- Fonds Erasme
- Fonds Yvonne Boel (Brussels, Belgium)
- European Regional Development Fund
- Walloon Region
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Background: Glioblastomas (GBMs) are the most common malignant primary brain tumours in adults and are refractory to conventional therapy, including surgical resection, radiotherapy and chemotherapy. The insulin-like growth factor (IGF) system is a complex network that includes ligands (IGFI and IGFII), receptors (IGF-IR and IGF-IIR) and high-affinity binding proteins (IGFBP-1 to IGFBP-6). Many studies have reported a role for the IGF system in the regulation of tumour cell biology. However, the role of this system remains unclear in GBMs. Methods: We investigate the prognostic value of both the IGF ligands' and receptors' expression in a cohort of human GBMs. Tissue microarray and image analysis were conducted to quantitatively analyse the immunohistochemical expression of these proteins in 218 human GBMs. Results: Both IGF-IR and IGF-IIR were overexpressed in GBMs compared with normal brain (P<10(-4) and P = 0.002, respectively). Moreover, with regard to standard clinical factors, IGF-IR positivity was identified as an independent prognostic factor associated with shorter survival (P = 0.016) and was associated with a less favourable response to temozolomide. Conclusions: This study suggests that IGF-IR could be an interesting target for GBM therapy.
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