New Cytotoxic Cytochalasans from a Plant-Associated Fungus Chaetomium globosum kz-19

Four new cytochalasans, phychaetoglobins A-D (1-4), together with twelve known cytochalasans (5-16), were isolated from a mangrove-associated fungus Chaetomium globosum kz-19. The new structures were elucidated on the basis of extensive 1D and 2D NMR, HR ESIMS spectroscopic analyses, and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established by application of Mosher's method. Compounds 4-8 exhibited moderate cytotoxicities against A549 and HeLa cell lines with the IC50 values less than 20 mu M.

Automated summary

In this study, four new cytochalasans and twelve known cytochalasans were isolated from a mangrove-associated fungus. The newly discovered compounds showed moderate cytotoxicity against A549 and HeLa cell lines. These findings provide valuable insights into the potential medicinal properties of these cytochalasans.