Journal
MARINE DRUGS
Volume 19, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/md19100530
Keywords
antibacterial; antifungal; antimicrobial; antiviral; marine bacteria; marine fauna; marine flora; marine sediments; marine water; secondary metabolites
Categories
Funding
- China Postdoctoral Science Foundation [2019M662214]
- Natural Science Foundation of China [32001798, 31972169, 32171435, 31670129]
- Program for Innovative Research Team in Fujian Agricultural and Forestry University [712018009]
- Key Laboratory ofMarine Biotechnology of Fujian Province [2020MB04]
- Key projects of Natural Science Foundation of Fujian Province [2020J02023]
- Fujian-Taiwan Joint Innovative Center for Germplasm Resources and Cultivation of Crop (FJ 2011 Program) [2015-75]
- National Key R&D Programof China [2017YFC1600100]
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Antimicrobial resistance is a growing concern that calls for the development of novel antimicrobial agents, with marine environment being a promising source for discovering bioactive compounds. Researchers have found that marine bacteria in diverse marine environments can produce unique antimicrobial agents, which show potential for combating drug-resistant pathogens.
The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996-2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.
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