Journal
MARINE DRUGS
Volume 19, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/md19060342
Keywords
marine-derived compounds; cancer therapy; mechanism; technology
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Funding
- Science and Technology Development Fund (FDCT), Macau SAR [019/2017/A1, 0055/2019/A1]
- Faculty of Health Sciences (FHS), University ofMacau (UM)
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Marine-derived compounds with anticancer properties have shown promising effects in impacting various cancer mechanisms, including anti-angiogenic, anti-proliferative, anti-metastasis activities, cell cycle arrest, and induction of apoptosis. These compounds are attracting growing interest and may become a significant component in future cancer treatments.
Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.
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