Importing genetically altered animals: ensuring quality

The reproducibility of research using laboratory animals requires reliable management of their quality, in particular of their genetics, health and environment, all of which contribute to their phenotypes. The point at which these biological materials are transferred between researchers is particularly sensitive, as it may result in a loss of integrity of the animals and/or their documentation. Here, we describe the various aspects of laboratory animal quality that should be confirmed when sharing rodent research models. We also discuss how repositories of biological materials support the scientific community to ensure the continuity of the quality of laboratory animals. Both the concept of quality and the role of repositories themselves extend to all exchanges of biological materials and all networks that support the sharing of these reagents.

Automated summary

Managing the quality of laboratory animals is crucial for the reproducibility of research, especially when sharing research models. Biological material repositories play a key role in ensuring the continuity of animal quality and supporting networks for sharing reagents. Quality control and the role of repositories are essential for all exchanges of biological materials in the scientific community.