Journal
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
Volume 34, Issue 6, Pages 877-887Publisher
SPRINGER
DOI: 10.1007/s10334-021-00935-y
Keywords
3D atrial LGE; Water; fat LGE; Respiratory motion-correction
Funding
- EPSRC [EP/P032311/1, EP/P007619/1, EP/P001009/1]
- Wellcome/EPSRC Centre for Medical Engineering [WT 203148/Z/16/Z]
- National Institute for Health Research (NIHR) Cardiovascular Health Technology Cooperative (HTC)
- Biomedical Research Centre based at Guy's and St. Thomas' NHS Foundation Trust and King's College London
- BHF programme [RG/20/1/34802]
- EPSRC [EP/P007619/1, EP/P001009/1, EP/P032311/1] Funding Source: UKRI
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The accelerated motion-compensated water/fat LGE technique provides atrial wall imaging with diagnostic quality comparable to the conventional method but with a significantly shorter scan time.
Objective 3D late gadolinium enhancement (LGE) imaging is a promising non-invasive technique for the assessment of atrial fibrosis. However, current techniques result in prolonged and unpredictable scan times and high rates of non-diagnostic images. The purpose of this study was to compare the performance of a recently proposed accelerated respiratory motion-compensated 3D water/fat LGE technique with conventional 3D LGE for atrial wall imaging. Materials and methods 18 patients (age: 55.7 +/- 17.1 years) with atrial fibrillation underwent conventional diaphragmatic navigator gated inversion recovery (IR)-prepared 3D LGE (dNAV) and proposed image-navigator motion-corrected water/fat IR-prepared 3D LGE (iNAV) imaging. Images were assessed for image quality and presence of fibrosis by three expert observers. The scan time for both techniques was recorded. Results Image quality scores were improved with the proposed compared to the conventional method (iNAV: 3.1 +/- 1.0 vs. dNAV: 2.6 +/- 1.0, p = 0.0012, with 1: Non-diagnostic to 4: Full diagnostic). Furthermore, scan time for the proposed method was significantly shorter with a 59% reduction is scan time (4.5 +/- 1.2 min vs. 10.9 +/- 3.9 min, p < 0.0001). The images acquired with the proposed method were deemed as inconclusive less frequently than the conventional images (expert 1/expert 2: 4/7 dNAV and 2/4 iNAV images inconclusive). Discussion The motion-compensated water/fat LGE method enables atrial wall imaging with diagnostic quality comparable to the current conventional approach with a significantly shorter scan of about 5 min.
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