Journal
MACROMOLECULES
Volume 54, Issue 14, Pages 6726-6744Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.1c00830
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Funding
- CNRS
- Ministere de l'Enseignement Superieur et de la Recherche Scientifique de Tunisie
- China Scholarship Council (CSC)
- GENCI [2020-A0080805032]
- departmental committee CD35 of the Ligue contre le Cancer du Grand-Ouest
- departmental committee CD49 of the Ligue contre le Cancer du Grand-Ouest
- departmental committee CD28 of the Ligue contre le Cancer du Grand-Ouest
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By changing the central porphyrin core to a phthalocyanine core in macromolecular structures, new dendrimers with multiple conjugated endgroups were prepared and studied. Efficient energy transfer from peripheral units to central unit led to intense red light emission and oxygen photosensitization, while significantly boosting two-photon absorption cross-sections. The impact of this structural change was discussed in relation to dendrimer generations using DFT and molecular dynamic calculations.
In the continuation of our sustained interest for porphyrin-based dendrimers and their use as luminescent photo-sensitizers for two-photon photodynamic therapy (2P-PDT), we wondered about the effect of changing the central porphyrin core for a phthalocyanine core in these macromolecular structures. Thus, related phthalocyanine-based dendrimers possessing up to 16 conjugated 9,9-dibutyl-2-fluorenyl endgroups at their periphery were now prepared and studied. As for porphyrin analogues, it was found that an efficient energy transfer occurs from the peripheral fluorenyl units toward the central phthalocyanine unit of these compounds, leading to intense red light emission and photosensitization of oxygen. While the linear optical properties of these new dendrimers are only slightly improved compared to those of their porphyrin-cored analogues for PDT and fluorescence imaging, their two-photon absorption (2PA) cross-sections are much more significantly boosted, evidencing the key role played by the central tetrapyrrolic unit in this respect. The impact of this structural change in relation with the impact resulting from the change in dendrimer generations is then discussed with the help of DFT and molecular dynamic calculations.
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