Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 42, Issue 21, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202100437
Keywords
antibacterial surfaces; polymer grafting; quaternary surfaces; surface functionalization; synthesis
Categories
Funding
- Innovation Fund Denmark
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Research on antibacterial surfaces has a history of more than 30 years, and applying antibacterial properties to commodity plastics is important. However, there is a need for developing simple methods for scalable production and addressing concerns of deactivation due to surface fouling.
Antibacterial surfaces have been researched for more than 30 years and remain highly desirable. In particular, there is an interest in providing antimicrobial properties to commodity plastics, because these, in their native state, are excellent substrates for pathogens to adhere and proliferate on. Therefore, efficient strategies for converting surfaces of commodity plastics into contact-active antimicrobial surfaces are of significant interest. Many systems have been prepared and tested for their efficacy. Here, the synthetic approaches to such active surfaces are reviewed, with the restriction to only include systems with tested antibacterial properties. The review focuses on the synthetic approach to surface functionalization of the most common materials used and tested for biomedical applications, which effectively has limited the study to quaternary materials. For future developments in the field, it is evident that there is a need for development of simple methods that permit scalable production of active surfaces. Furthermore, in terms of efficacy, there is an outstanding concern of a lack of universal antimicrobial action as well as rapid deactivation of the antibacterial effect through surface fouling.
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