Journal
MACROMOLECULAR MATERIALS AND ENGINEERING
Volume 306, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mame.202100171
Keywords
biodegradable polymers; microneedles; skin patches; transdermal drug delivery
Funding
- Tohoku University Frontier Research program (FRiD)
- Ministry of Education, Culture, Sports, Science and Technology, Japan [18H04158, 19K15598, 20K21877]
- Grants-in-Aid for Scientific Research [19K15598, 18H04158, 20K21877] Funding Source: KAKEN
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An array of porous microneedles made of PLGA was fabricated with a porosity around 50% through a combination of molding and freeze-drying methods. The mechanical strength of the PLGA microneedles was enhanced by modification with CMC, resulting in decreased transdermal resistance, thus improving efficiency and safety of DC current-based transdermal techniques.
An array of porous microneedles (PMNs) made of biodegradable poly(lactic-co-glycolic acid) (PLGA) is fabricated by a combination of molding and freeze-drying methods. The optimized mixture of PLGA and 1,4-dioxane is poured into a mold of a microneedle array, followed by the freezing and sublimation of the frozen particles of 1,4-dioxane, a procedure that left an interconnecting porous structure in the PLGA with a porosity around 50%. The mechanical strength of the PMN made of PLGA (PLGA-PMN) is reinforced by modification with carboxymethylcellulose (CMC), resulting in sufficient strength enough for insertion into an excised porcine skin. The transdermal resistance is significantly decreased by the CMC-modified PLGA-PMN, which would improve the efficiency and safety of DC current-based transdermal techniques, including the electrical monitoring of the skin condition and iontophoresis for drug delivery and medical diagnosis.
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