Journal
LIVER INTERNATIONAL
Volume 41, Issue 11, Pages 2547-2559Publisher
WILEY
DOI: 10.1111/liv.15054
Keywords
anti-inflammatory; hepatic viruses; innate immunity; interferon; liver; MHC; NF-kappa B; pro-inflammatory; PRR
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Funding
- German-Israeli Cooperation in Cancer Research (DKFZ-MOST)
- INSERM (Institut National de la Sante et de la Recherche Medicale)
- ANRS (Agence Nationale de Recherche sur le Sida et les hepatites virales)
- [SFBTR179]
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Hepatitis viruses have developed various strategies to counteract liver innate immunity, including passive entry or active evasion from immune recognition, modulation of pattern recognition receptor expression and/or signaling pathways, modulation of interferon response, and modulation of immune cells count or phenotype.
In their never-ending quest towards persistence within their host, hepatitis viruses have developed numerous ways to counteract the liver innate immunity. This review highlights the different and common mechanisms employed by these viruses to (i) establish in the liver (passive entry or active evasion from immune recognition) and (ii) actively inhibit the innate immune response (ie modulation of pattern recognition receptor expression and/or signalling pathways, modulation of interferon response and modulation of immune cells count or phenotype).
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