Journal
LIFE SCIENCES
Volume 278, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2021.119579
Keywords
Taurine; Hyperlipidemia; Cholesterol; Gut microbiota; Autophagy; Metabolic reprogramming
Funding
- National Natural Science Foundation of China [81771774]
- Anhui Key Research and Development Foundation [201904a07020103]
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Hyperlipidemia, an independent risk factor for atherosclerosis, is often associated with lipid metabolism disorder. Taurine, a sulfur-containing nonessential amino acid abundant in marine foods, plays a crucial role in regulating lipid metabolism.
Hyperlipidemia, an independent risk factor for atherosclerosis, is regarded as a lipid metabolism disorder associated with elevated plasma triglyceride and/or cholesterol. Genetic factors and unhealthy lifestyles, such as excess caloric intake and physical inactivity, can result in hyperlipidemia. Taurine, a sulfur-containing nonessential amino acid, is abundant in marine foods and has been associated with wide-ranging beneficial physiological effects, with special reference to regulating aberrant lipid metabolism. Its anti-hyperlipidemic mechanism is complex, which is related to many enzymes in the process of fat anabolism and catabolism (e.g., HMGCR, CYP7A1, LDLR, FXR, FAS and ACC). Anti-inflammatory and antioxidant molecular targets, lipid autophagy, metabolic reprogramming and gut microbiota will also be reviewed.
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