Related references
Note: Only part of the references are listed.
Article
Infectious Diseases
Zhiwei Wu et al.
Summary: The study showed that CoronaVac vaccine is safe and well tolerated in older adults, and is able to induce neutralizing antibody levels. The highest dose of 3 μg of the vaccine can generate neutralizing antibody levels similar to the 6 μg dose, supporting the use of the 3 μg dose CoronaVac in phase 3 trials.
LANCET INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yanjun Zhang et al.
Summary: This study investigated the safety, tolerability, and immunogenicity of the COVID-19 vaccine candidate CoronaVac, and found that the 3 μg dose showed higher seroconversion rates in the phase 2 trial.
LANCET INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Noa Dagan et al.
Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Medicine, General & Internal
Maya Moshe et al.
Summary: The study evaluated the performance of new lateral flow immunoassays (LFIAs) for detecting SARS-CoV-2 antibodies in a national COVID-19 seroprevalence program. Seven LFIAs showed sensitivity ranging from 69% to 100% and specificity from 98.6% to 100%. One LFIA was identified with suitable clinical performance for potential inclusion in seroprevalence studies, but none showed superior performance for routine clinical use compared to the current LFIA.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Eleftheria Vasileiou et al.
Summary: The study in Scotland found that the first doses of the BNT162b2 mRNA and ChAdOx1 vaccines were associated with substantial reductions in the risk of COVID-19 hospital admission, with vaccine effectiveness ranging from 88% to 91% at 28-34 days post-vaccination.
Article
Biochemistry & Molecular Biology
David S. Khoury et al.
Summary: The level of neutralizing antibodies is closely related to immune protection against COVID-19, playing a crucial role in protecting against detected infection and severe infection. Studies have shown that neutralizing titers will decline over time after vaccination, leading to decreased protection against SARS-CoV-2 infection.
Article
Biochemistry & Molecular Biology
Jingxin Li et al.
Summary: The messenger RNA vaccine candidate BNT162b1, encoding the receptor-binding domain of the SARS-CoV-2 spike protein, showed safety and high levels of humoral and T cell responses in an Asian population, including younger and older Chinese adults. Local reactions and systemic events post-vaccination were generally dose-dependent, transient, and mild to moderate.
Article
Multidisciplinary Sciences
Dami A. Collier et al.
Summary: Elderly individuals, especially those above eighty, show lower immune responses and neutralization abilities against variants of concern after the first vaccine dose, but this improves after the second dose. They have higher frequencies of spike-specific memory B cells but reduced somatic hypermutation of class-switched cells. Production of interferon-gamma and interleukin-2 by SARS-CoV-2 spike-specific T cells is lower in older participants, predominantly by CD4 T cells.
Article
Medicine, General & Internal
Alejandro Jara et al.
Summary: A study in Chile involving 10.2 million participants assessed the effectiveness of an inactivated SARS-CoV-2 vaccine developed in China. Fully immunized individuals had vaccine effectiveness of 65.9% for preventing Covid-19 and 87.5% for preventing hospitalization, 90.3% for preventing ICU admission, and 86.3% for preventing death.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Immunology
Kristen A. Earle et al.
Summary: The study found a strong correlation between antibody titers and efficacy when assessing different COVID-19 vaccines, supporting the use of post-immunization antibody titers as the basis for establishing a correlate of protection for COVID-19 vaccines.
Article
Health Policy & Services
Fiona Sim
Summary: Early, rapid, nationally orchestrated vaccine rollout has been a feature in the responses of Israel and the UK to the global coronavirus pandemic. The factors influencing the early days of the rollout in these two countries could provide valuable lessons for other countries grappling with planning their own Covid-19 vaccine programmes.
ISRAEL JOURNAL OF HEALTH POLICY RESEARCH
(2021)
Review
Immunology
Stephanie Fischinger et al.
SEMINARS IN IMMUNOPATHOLOGY
(2019)
Article
Mathematics, Applied
Jeff Bezanson et al.