Journal
FRONTIERS IN BIOSCIENCE-LANDMARK
Volume 21, Issue -, Pages 1-7Publisher
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4371
Keywords
MicroRNAs; Adrenocorticotropic hormone; Let-7; Review
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Funding
- [30304117323]
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Pituitary tumors, the most common intracranial tumors, lead to serious morbidity through the inappropriate secretion of pituitary hormones. The anomalous expression of microRNAs ( miRNAs), which have a crucial status in the development and function of pituitary gland, promotes the tumorigenesis of hypothalamic-pituitary axis-related pituitary tumors. This mainly leads to alterations in the function of the hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-growth hormone. In the tumorigenesis of pituitary tumors, miRNAs have complex roles. They can induce cell cycle arrest, inhibiting cell proliferation and inducing apoptosis via different pathways; however, they also promote the occurrence of pituitary tumors through direct interactions with transcription factors. This review summarizes recent progress in the study of miRNAs on the pathogenesis of pituitary tumors.
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