Journal
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
Volume 76, Issue 11, Pages 2062-2070Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab221
Keywords
Dementia; Diabetes duration; Glycemic control
Categories
Funding
- Open Project of Guangdong Provincial Key Laboratory of Tropical Disease Research and Guangdong Basic and Applied Basic Research Foundation
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This study investigated the influence of diabetes duration and glycemic control on the risk of incident dementia. The findings showed that individuals with diabetes have a higher risk of dementia compared to those with normal glucose levels, and this risk increases with longer duration of diabetes. Additionally, it was found that both longer diabetes duration and poor glycemic control were associated with the highest risk of dementia, highlighting the importance of considering both factors in dementia risk assessments for diabetic patients.
Background: To investigate the influence of diabetes duration and glycemic control, assessed by glycated hemoglobin (HbA1c) levels, on risk of incident dementia. Methods: The present study is a prospective study of 461 563 participants from the UK Biobank. The age at diabetes diagnosis was determined by self-report. Diabetes duration was calculated as baseline age minus age at diagnosis. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) with 95% confidential intervals (CIs). Results: During a median follow-up of 8.1 years, 2 233 dementia cases were recorded. As compared with normoglycemic individuals, individuals with diabetes had higher risk of all-cause dementia, and the risk increased with increasing duration of diabetes; compared with participants with diabetes duration of <5 years, the multivariable-adjusted HRs (95% CIs) were 1.49 (1.12-1.97), 1.71 (1.21-2.41), and 2.15 (1.60-2.90) for those with diabetes durations >= 5 to < 10, >= 10 to <15, and >= 15 years, respectively (p for trend < .001). Among participants with diabetes, those with both longer diabetes duration (diabetes duration >= 10 years) and poor glycemic control (HbA1c >= 8%) had the highest risk of all-cause dementia (multivariable-adjusted HR = 2.07, 95% CI 1.45, 2.94), compared with patients with shorter duration of diabetes and better glycemic control (diabetes duration < 10 years and HbA1c < 8%). Conclusions: Diabetes duration appeared to be associated with the risk of incident dementia due to factors beyond glycemic control. Clinicians should consider not only glycemic control but also diabetes duration in dementia risk assessments for patients with diabetes.
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