Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 98, Issue -, Pages 218-230Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2015.12.031
Keywords
Skeletal muscle loss; MuRF-1; MAFbx; Ubiquitin-proteasome system
Funding
- Rappaport Institute
- Krol Foundation of Barnegat N.J.
- Myers-JDC Brookdale Institute of Gerontology and Human Development
- ESHEL - the Association for Planning and Development of Services for the Aged in Israel
Ask authors/readers for more resources
The ubiquitin-proteasome system (UPS) is the main regulatory mechanism of protein degradation in skeletal muscle. The ubiquitin-ligase enzymes (E3s) have a central role in determining the selectivity and specificity of the UPS. Since their identification in 2001, the muscle specific E3s, muscle RING finger-1 (MuRF-1) and muscle atrophy F-box (MAFbx), have been shown to be implicated in the regulation of skeletal muscle atrophy in various pathological and physiological conditions. This review aims to explore the involvement of MuRF-1 and MAFbx in catabolism of skeletal muscle during various pathologies, such as cancer cachexia, sarcopenia of aging, chronic kidney disease (CKD), diabetes, and chronic obstructive pulmonary disease (COPD). In addition, the effects of various lifestyle and modifiable factors (e.g. nutrition, exercise, cigarette smoking, and alcohol) on MuRF-1 and MAFbx regulation will be discussed. Finally, evidence of potential strategies to protect against skeletal muscle wasting through inhibition of MuRF-1 and MAFbx expression will be explored. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available