Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-021-02978-0
Keywords
Radiation induced lung injury; GSTP1; Inflammatory response; Fibrosis
Categories
Funding
- National Natural Science Foundation of China [82003387]
- Military Research Plan [20BJZ40]
- Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital [NCRCG-PLAGH-2020003]
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GSTP1, an isoenzyme in the glutathione-S transferases enzyme system, is closely associated with the risk of radiation induced lung injury (RILI) development. It may play a role in RILI by regulating cell oxidative stress, inhibiting cell apoptosis, and promoting cytotoxic metabolism.
The glutathione S-transferase P1(GSTP1) is an isoenzyme in the glutathione-S transferases (GSTs) enzyme system, which is the most abundant GSTs expressed in adult lungs. Recent research shows that GSTP1 is closely related to the regulation of cell oxidative stress, inhibition of cell apoptosis and promotion of cytotoxic metabolism. Interestingly, there is evidence that GSTP1 single nucleotide polymorphisms (SNP) 105Ile/Val related to the risk of radiation induced lung injury (RILI) development, which strongly suggests that GSTP1 is closely associated with the occurrence and development of RILI. In this review, we discuss our understanding of the role of GSTP1 in RILI and its possible mechanism.
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