4.7 Article

Pan-cancer characterization of metabolism-related biomarkers identifies potential therapeutic targets

Related references

Note: Only part of the references are listed.
Review Oncology

Targeting Oxidative Phosphorylation to Increase the Efficacy of Radio- and Immune-Combination Therapy

Daan F. Boreel et al.

Summary: As tumors grow, they increase glycolytic and oxidative metabolism to meet energy demands, affecting the tumor microenvironment. Hypoxia, a result of chaotic vasculature, leads to immune cell dysfunction and promotes immunosuppressive activity, impacting the efficacy of radiotherapy and immunotherapy. Inhibitors of oxidative phosphorylation show promise in reducing tumor hypoxia and enhancing the immune response, potentially improving outcomes of combined radio- and immunotherapy.

CLINICAL CANCER RESEARCH (2021)

Article Oncology

The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer

Atsushi Fujii et al.

Summary: The study identified ASAP2 as a novel driver gene in PDAC, with high expression contributing to a poor prognosis and promoting tumor growth by facilitating cell cycle progression. Niclosamide, repositioned as a drug targeting the ASAP2 pathway, suppresses PDAC growth by inhibiting ASAP2 expression.

CANCER SCIENCE (2021)

Article Hematology

Targeting AXL kinase sensitizes leukemic stem and progenitor cells to venetoclax treatment in acute myeloid leukemia

Xiaojia Niu et al.

Summary: The study demonstrates that inhibiting the AXL pathway in AML stem/progenitor cells in combination with venetoclax can target intrinsic metabolic vulnerabilities and show distinct transcriptomic profiles, impacting the treatment of AML and other cancers with high AXL activity.

BLOOD (2021)

Article Hematology

Very long chain fatty acid metabolism is required in acute myeloid leukemia

Matthew Tcheng et al.

Summary: By studying the metabolic characteristics of AML cells, it was found that the FAO enzyme VLCAD plays a crucial role in mitochondrial metabolism and cell survival. Inhibiting VLCAD leads to AML cell death while having no impact on normal hematopoietic cells.

BLOOD (2021)

Article Biochemistry & Molecular Biology

ATM inhibitor KU-55933 induces apoptosis and inhibits motility by blocking GLUT1-mediated glucose uptake in aggressive cancer cells with sustained activation of Akt

Benjamin R. E. Harris et al.

Summary: Enhanced glucose uptake in cancer cells is closely correlated with poor prognosis, and the protein kinase ATM plays a key role in insulin-mediated glucose uptake. Inhibition of ATM by KU-55933 inhibits glucose uptake and glycolysis, induces apoptosis, and inhibits motility of cancer cells with overactivated Akt, showing potential as a therapeutic agent against cancer.

FASEB JOURNAL (2021)

Review Multidisciplinary Sciences

Metabolic reprogramming and cancer progression

Brandon Faubert et al.

SCIENCE (2020)

Review Cell Biology

Mitochondrial Metabolism as a Target for Cancer Therapy

Karthik Vasan et al.

CELL METABOLISM (2020)

Article Gastroenterology & Hepatology

Mitochondrial oxidative metabolism contributes to maintain a cancer stem cell phenotype in cholangiocarcinoma

Chiara Raggi et al.

JOURNAL OF HEPATOLOGY (2020)

Article Cell Biology

MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer

Shine-Gwo Shiah et al.

JOURNAL OF BIOMEDICAL SCIENCE (2020)

Review Oncology

Role of MicroRNA-30c in cancer progression

Wenyan Han et al.

JOURNAL OF CANCER (2020)

Article Multidisciplinary Sciences

Metabolic landscape of the tumor microenvironment at single cell resolution

Zhengtao Xiao et al.

NATURE COMMUNICATIONS (2019)

Article Oncology

MicroRNA 362-3p Reduces hERG-related Current and Inhibits Breast Cancer Cells Proliferation

Abdullah A. Assiri et al.

CANCER GENOMICS & PROTEOMICS (2019)

Article Biochemistry & Molecular Biology

The Reactome Pathway Knowledgebase

Antonio Fabregat et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Biochemistry & Molecular Biology

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

Tathiane M. Malta et al.

Article Biochemical Research Methods

ARACNe-AP: gene network reverse engineering through adaptive partitioning inference of mutual information

Alexander Lachmann et al.

BIOINFORMATICS (2016)

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

Hui Zhang et al.

Article Biochemistry & Molecular Biology

A Landscape of Pharmacogenomic Interactions in Cancer

Francesco Iorio et al.

Article Multidisciplinary Sciences

Proteogenomics connects somatic mutations to signalling in breast cancer

Philipp Mertins et al.

NATURE (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Review Oncology

Oxygen availability and metabolic adaptations

Michael S. Nakazawa et al.

NATURE REVIEWS CANCER (2016)

Review Cell Biology

Metabolic pathways promoting cancer cell survival and growth

Lindsey K. Boroughs et al.

NATURE CELL BIOLOGY (2015)

Review Cell Biology

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Flore Kruiswijk et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Review Oncology

MYC, Metabolism, and Cancer

Zachary E. Stine et al.

CANCER DISCOVERY (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Biochemical Research Methods

ChAMP: 450k Chip Analysis Methylation Pipeline

Tiffany J. Morris et al.

BIOINFORMATICS (2014)

Article Multidisciplinary Sciences

Copy number alteration burden predicts prostate cancer relapse

Haley Hieronymus et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Cell Biology

A Mitochondrial Switch Promotes Tumor Metastasis

Paolo E. Porporato et al.

CELL REPORTS (2014)

Article Cell Biology

Characterization of the Usage of the Serine Metabolic Network in Human Cancer

Mahya Mehrmohamadi et al.

CELL REPORTS (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Oncology

Acidity Generated by the Tumor Microenvironment Drives Local Invasion

Veronica Estrella et al.

CANCER RESEARCH (2013)

Article Biotechnology & Applied Microbiology

Heterogeneity of tumor-induced gene expression changes in the human metabolic network

Jie Hu et al.

NATURE BIOTECHNOLOGY (2013)

Review Cell Biology

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

Christian C. Dibble et al.

NATURE CELL BIOLOGY (2013)

Article Genetics & Heredity

Pan-cancer patterns of somatic copy number alteration

Travis I. Zack et al.

NATURE GENETICS (2013)

Article Multidisciplinary Sciences

Systematic identification of genomic markers of drug sensitivity in cancer cells

Mathew J. Garnett et al.

NATURE (2012)

Article Multidisciplinary Sciences

Identification and Functional Expression of the Mitochondrial Pyruvate Carrier

Sebastien Herzig et al.

SCIENCE (2012)

Article Multidisciplinary Sciences

A Mitochondrial Pyruvate Carrier Required for Pyruvate Uptake in Yeast, Drosophila, and Humans

Daniel K. Bricker et al.

SCIENCE (2012)

Review Biochemistry & Molecular Biology

Hallmarks of Cancer: The Next Generation

Douglas Hanahan et al.

Article Computer Science, Interdisciplinary Applications

miRWalk - Database: Prediction of possible miRNA binding sites by walking the genes of three genomes

Harsh Dweep et al.

JOURNAL OF BIOMEDICAL INFORMATICS (2011)

Article Biochemical Research Methods

ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking

Matthew D. Wilkerson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

A human B-cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Celine Lefebvre et al.

MOLECULAR SYSTEMS BIOLOGY (2010)

Review Multidisciplinary Sciences

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Matthew G. Vander Heiden et al.

SCIENCE (2009)

Review Cell Biology

The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation

Ralph J. DeBerardinis et al.

CELL METABOLISM (2008)

Article Oncology

Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung

Julien D. F. Licchesi et al.

CLINICAL CANCER RESEARCH (2008)

Review Biochemistry & Molecular Biology

PI3K pathway alterations in cancer: variations on a theme

T. L. Yuan et al.

ONCOGENE (2008)

Article Biochemical Research Methods

Extensions to gene set enrichment

Zhen Jiang et al.

BIOINFORMATICS (2007)

Article Medicine, Research & Experimental

Aberrant CpG island hypermethylation of multiple genes in colorectal neoplasia

S Lee et al.

LABORATORY INVESTIGATION (2004)