Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-021-02960-w
Keywords
Advanced oxidation protein products; All-cause mortality; Cardiovascular mortality; Hemodialysis patients
Categories
Funding
- National Natural Science Foundation of China [82070790]
- Nature Science Foundation of Guangdong Province [2014A030313345]
- Clinical Innovation Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2018GZR0201003]
- Research Fund Program of Guangdong Provincial Key Laboratory of Renal Failure Research [2017B030314036]
- Major International (Regional) Joint Research Project [81620108003]
- National Innovation Team Program [81521003]
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This study aimed to assess the correlation of serum advanced oxidation protein products (AOPP) levels with the risk of all-cause mortality in hemodialysis (HD) patients in China. The results showed that elevated serum AOPP levels were associated with a higher risk of all-cause mortality in Chinese maintenance HD patients, particularly in those with AOPP levels >=87 mu mol/L.
BackgroundThe association between serum advanced oxidation protein products (AOPP) and mortality risk remains equivocal. We aimed to assess the correlation of serum AOPP levels with the risk of all-cause mortality in hemodialysis (HD) patients.MethodsA total of 1394 maintenance HD patients with complete data on AOPP and related parameters were included from China Collaborative Study on Dialysis (CCSD), a multi-center, prospective cohort study. The primary outcome was all-cause mortality, the secondary outcome was cardiovascular disease (CVD) mortality.ResultsDuring a median follow-up duration of 5.2 years (IQR, 2.1-5.4), all-cause mortality occurred in 492 (31.4%) participants. Overall, there was a reversed L-shaped association between serum AOPP and all-cause mortality in HD patients (P for nonlinearity=0.04), with an inflection point at 87 mu mol/L. Accordingly, there was no significant association between serum AOPP and all-cause mortality (per SD increment; HR, 0.94; 95%CI, 0.84, 1.05) in participants with AOPP<87 mol/L. However, there was a positive relationship of serum AOPP and all-cause mortality (per SD increment; HR, 1.24; 95%CI, 1.08, 1.42) in those with AOPP >= 87 mu mol/L. Moreover, a similar trend was found for CVD mortality.ConclusionsElevated serum AOPP levels were associated with higher risk of all-cause mortality in Chinese maintenance HD patients.
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