Journal
JOURNAL OF TRANSLATIONAL MEDICINE
Volume 19, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12967-021-02892-5
Keywords
Parkinson's disease; Vitamin C; Genome-wide association study; Mendelian randomization; Inverse-variance weighted
Categories
Funding
- National Natural Science Foundation of China [82071212, 81901181]
- Mathematical Tianyuan Fund of the National Natural Science Foundation of China [12026414]
- Beijing Ten Thousand Talents Project [2020A15]
- Science and Technology Beijing One Hundred Leading Talent Training Project [Z141107001514006]
- Beijing Municipal Administration of Hospitals' Mission Plan [SML20150802]
- Shandong Academy of Medical Sciences [2019QL016, 2019PT007]
- Funds of Academic Promotion Programme of Shandong First Medical University
Ask authors/readers for more resources
The study found a negative trend between genetically increased plasma vitamin C levels and Parkinson's disease age at onset (AAO), although there was no significant association with PD occurrence. This suggests that vitamin C may have an impact on the AAO of PD, but further research is needed to confirm this.
Background: Until now, epidemiological evidence regarding the association between vitamin C intake (both diet and supplements) and Parkinson's disease (PD) remains inconsistent. Hence, it is necessary to establish the causal link between vitamin C levels and PD, and further develop effective therapies or prevention. Methods: We selected 11 newly identified plasma vitamin C genetic variants from a large-scale plasma vitamin C GWAS dataset (n = 52,018) as the effective instrumental variables, and extracted their corresponding GWAS summary statistics from PD (33,674 PD cases and 449,056 controls) and PD age at onset (AAO) (n = 28,568). We then performed a Mendelian randomization (MR) study to evaluate the causal association of plasma vitamin C levels with PD and PD AAO using inverse-variance weighted (IVW), the weighted median, MR-Egger, and MR-PRESSO test. Results: We did not observe any significant association between genetically increased vitamin C levels and PD. Interestingly, we found a reduced trend of PD AAO (1.134 years) with 1 SD genetically increased vitamin C levels using IVW (beta = - 1.134, 95% CI: [- 2.515, 0.248], P = 0.108). Importantly, this trend was further successfully verified using both weighted median and MR-Egger. Each 1 SD genetically increased vitamin C levels could reduce PD AAO 1.75 and 2.592 years using weighted median (beta = - 1.750, 95% CI: [- 3.396, - 0.105], P = 0.037) and MR-Egger (beta = - 2.592, 95% CI: [- 4.623, - 0.560], P = 0.012). Conclusions: We demonstrated the causal association between genetically increased plasma vitamin C levels and reduced PD AAO in people of European descent. Randomized controlled trials are required to clarify whether diet intake or supplement, or both could reduce the AAO of PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available