Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 15, Issue 11, Pages 915-935Publisher
WILEY
DOI: 10.1002/term.3239
Keywords
antimicrobial; bone tissue engineering; graphene; osteoinductive
Categories
Funding
- National Natural Science Foundation of China [81771048, 81870743]
- Key Project of the Science and Technology Department of Sichuan Province [2020YFSY0019]
Ask authors/readers for more resources
Graphene-based materials (GMs) have great potential in bone tissue engineering due to their ability to induce osteogenesis and antimicrobial properties by regulating various pathways and mechanisms. GMs prevent microbial adhesion and kill them through reducing surface free energy and increasing hydrophobicity, as well as inducing oxidative stress and photothermal/photodynamic effects.
Graphene-based materials (GMs) have great application prospects in bone tissue engineering due to their osteoinductive ability and antimicrobial activity. GMs induce osteogenic differentiation through several mechanisms and pathways in bone tissue engineering. First of all, the surface and high hardness of the porous folds of graphene or graphene oxide (GO) can generate mechanical stimulation to initiate a cascade of reactions that promote osteogenic differentiation without any chemical inducers. In addition, change of the extracellular matrix (ECM), regulation of macrophage polarization, the oncostatin M (OSM) signaling pathway, the MAPK signaling pathway, the BMP signaling pathway, the Wnt/beta-catenin signaling pathway, and other pathways are involved in GMs' regulation of osteogenesis. In bone tissue engineering, GMs prevent the formation of microbial biofilms mainly through preventing microbial adhesion and killing them. The former is mainly achieved by reducing surface free energy (SFE) and increasing hydrophobicity. The latter mainly includes oxidative stress and photothermal/photodynamic effects. Graphene and its derivatives (GDs) are mainly combined with bioactive ceramic materials, metal materials and macromolecular polymers to play an antimicrobial effect in bone tissue engineering. Concentration, number of layers, and type of GDs often affect the antimicrobial activity of GMs. In this paper, we reviewed relevant osteoinductive and antimicrobial mechanisms of GMs and their applications in bone tissue engineering.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available