4.6 Article

Paxillin binding to the PH domain of kindlin-3 in platelets is required to support integrin αIIbβ3 outside-in signaling

Related references

Note: Only part of the references are listed.
Article Hematology

Kindlin-3 recruitment to the plasma membrane precedes high-affinity β2-integrin and neutrophil arrest from rolling

Lai Wen et al.

Summary: The study demonstrated the essential role of kindlin-3 in neutrophil adhesion, with its PH domain playing a crucial role in recruitment to the plasma membrane.

BLOOD (2021)

Article Biology

Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions

Marta Ripamonti et al.

Summary: The study provides insights into the molecular organization of beta 3 integrin-FAs, showing the specific contributions of individual Paxillin LIM domains in targeting and maintaining the structural integrity of focal adhesions (FAs). Ripamonti et al. demonstrate the importance of mechanical coupling of paxillin in the FA to the plasma membrane or integrin for FA stability and integrin-talin linkage.

COMMUNICATIONS BIOLOGY (2021)

Review Hematology

Platelet MAPKs-a 20+year history: What do we really know?

Pravin Patel et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

Article Biochemistry & Molecular Biology

Structural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state

Wenting Bu et al.

PLOS BIOLOGY (2020)

Article Cell Biology

A kindlin-3-leupaxin-paxillin signaling pathway regulates podosome stability

Sarah Klapproth et al.

JOURNAL OF CELL BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion

Liang Zhu et al.

STRUCTURE (2019)

Review Hematology

Negative regulators of platelet activation and adhesion

L. Stefanini et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2018)

Review Hematology

Platelet Signaling Pathways and New Inhibitors

Steven P. Grover et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)

Article Cell Biology

Peptides derived from the integrin β cytoplasmic tails inhibit angiogenesis

Zhongyuan Cao et al.

CELL COMMUNICATION AND SIGNALING (2018)

Article Biochemistry & Molecular Biology

Structure and lipid-binding properties of the kindlin-3 pleckstrin homology domain

Tao Ni et al.

BIOCHEMICAL JOURNAL (2017)

Article Cell Biology

The kindlin family: functions, signaling properties and implications for human disease

Emanuel Rognoni et al.

JOURNAL OF CELL SCIENCE (2016)

Review Cardiac & Cardiovascular Systems

Integrin αIIbβ3 From Discovery to Efficacious Therapeutic Target

Kamila Bledzka et al.

CIRCULATION RESEARCH (2013)

Article Biochemistry & Molecular Biology

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

Feng Ye et al.

CURRENT BIOLOGY (2013)

Review Hematology

Rho GTPases in platelet function

J. E. Aslan et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2013)

Article Biochemistry & Molecular Biology

Structural and Functional Characterization of the Kindlin-1 Pleckstrin Homology Domain

Luke A. Yates et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Biochemistry & Molecular Biology

Structural Basis of Phosphoinositide Binding to Kindlin-2 Protein Pleckstrin Homology Domain in Regulating Integrin Activation

Jianmin Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Hematology

Antithrombotic effects of targeting αIIbβ3 signaling in platelets

Ararat J. Ablooglu et al.

BLOOD (2009)

Article Hematology

LAD-1/variant syndrome is caused by mutations in FERMT3

Taco W. Kuijpers et al.

BLOOD (2009)

Article Hematology

Kindling the flame of integrin activation and function with kindlins

Edward F. Plow et al.

CURRENT OPINION IN HEMATOLOGY (2009)

Article Biochemistry & Molecular Biology

Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells

Markus Moser et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

Nikolay L. Malinin et al.

NATURE MEDICINE (2009)

Article Biochemistry & Molecular Biology

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

Lena Svensson et al.

NATURE MEDICINE (2009)

Review Multidisciplinary Sciences

The Tail of Integrins, Talin, and Kindlins

Markus Moser et al.

SCIENCE (2009)

Review Biochemistry & Molecular Biology

Kindlins: essential regulators of integrin signalling and cell-matrix adhesion

Hannu Larjava et al.

EMBO REPORTS (2008)

Article Biochemistry & Molecular Biology

Kindlin-3 is essential for integrin activation and platelet aggregation

Markus Moser et al.

NATURE MEDICINE (2008)

Article Biochemistry & Molecular Biology

Structural basis of integrin activation by talin

Kate L. Wegener et al.

Article Oncology

The Kindlins:: Subcellular localization and expression during murine development

Siegfried Ussar et al.

EXPERIMENTAL CELL RESEARCH (2006)

Review Physiology

Paxillin: Adapting to change

MC Brown et al.

PHYSIOLOGICAL REVIEWS (2004)

Review Biochemistry & Molecular Biology

Platelets in atherothrombosis

ZM Ruggeri

NATURE MEDICINE (2002)

Review Biochemistry & Molecular Biology

Integrins: Bidirectional, allosteric signaling machines

RO Hynes