Design, Synthesis, and Evaluation of New Colorimetric Chemosensors Containing Quinazolinones Moiety for some Cations Detection in an Aqueous Medium and Biological Sample

The current project deals with designing and synthesizing of colorimetric chemosensors to detect the cations in the aqueous medium and biological sample. To achieve this goal a new series of quinazolinone derivatives were synthesized via reaction of the novel 6-nitro-2-propyl-4H-benzo [d] [1,3]oxazin-4-one (3) with selected nitrogen nucleophiles, namely, formamide, hydrazine hydrate, hydroxylamine hydrochloride, O-phenylendiamine, O-aminophenol and O-aminothiophenol, urea and/or thiourea. Structures of the new compounds have been investigated depending on their spectral data (IR, (HNMR)-H-1, C-13 NMR and MS) and elemental analyses. Some of the newly synthesized products exhibited a significant response as chemosensors for some cations detection. The synthesized chemosensors 11(a) and 11(b) showed high-selectivity and specificity towards cooper (Cu-II) and mercury (Hg-II) cations detection through exhibiting colormetric responses. Chemosensors 7 and 10(b) showed high selectivity toward cadmium (Cd-II) cation, whilst other examined compounds (9(b,c), 10(a), 12, 13, and 14) did not exhibit colorimetric response in all cation's samples.

Automated summary

A series of new colorimetric chemosensors have been synthesized to detect cations in aqueous medium and biological sample, with some showing significant response to certain cations. Chemosensors 11(a) and 11(b) demonstrated high selectivity and specificity for copper (Cu-II) and mercury (Hg-II) cations, while chemosensors 7 and 10(b) showed high selectivity for cadmium (Cd-II) cation.