Journal
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
Volume 41, Issue 15, Pages 7921-7934Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.jeurceramsoc.2021.07.058
Keywords
Nagelschmidtite; Biomineralization; Apatite biomimetics; TEM
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Funding
- National Council of Science and Technology (Mexico)
- CIDESI (CONACYT project FORDECYT-PRONACES) [618306]
- Generalitat de Catalunya from Spain [SGR-1777]
- Spanish Government [MAT2016-76928-C2-1-R]
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The Nagelschmidtite phase has the ability to promote osteogenesis, cementogenesis, and angiogenesis, with its chemical and structural properties affecting the formation and crystallization mechanism of apatite. The bioceramic exhibits a biomimetic behavior during apatite biomineralization, comparable to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems.
The ability of the Nagelschmidtite (Nagel) phase to promote osteogenesis, cementogenesis, and angiogenesis increased the interest in using this calcium silicophosphate bioceramic for tissue regeneration and vascularization applications. Nagel phase is a solid solution with the general formula Ca7-xNax(PO4) (2+x)(SiO4)(2-x), which allows several substitutions being Ca-7(PO4)(2)(SiO4) (2) the most reported stoichiometry. Inspired by the well-known 45S5 bioactive glass chemical composition, we developed a synthesis route to obtain a Na-rich Nagel single phase. The effect of this bioceramic chemical and structural properties on apatite formation and crystallization mechanism is reported. The structural aspects at the nano and microscale of the mechanism of apatite growth and crystallization from the Nagel phase were compared to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems, revealing a biomimetic behavior during the apatite biomineralization process from the bioceramic.
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